Synthesis and antibacterial activity of arylpiperazinyl oxazolidiniones with diversification of the N-substituents

被引：28

作者：

Jang, SY

Ha, YH

Ko, SW

Lee, W ^{[1
]}

Lee, J

Kim, S

Kim, YW

Lee, WK ^{[1
]}

Ha, HJ

机构：

[1] Seoul Natl Univ, Imagene Co Ltd, Biotechnol Incubating Ctr, Seoul 151742, South Korea

[2] Seoul Natl Univ, Ctr ARS Network, Coll Pharm, Seoul 151741, South Korea

[3] Sogang Univ, Dept Chem, Seoul 121742, South Korea

[4] Hankuk Univ Foreign Studies, Dept Chem, Yongin 449791, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 15期

关键词：

antibacterial; oxazolidinone; thioamide;

D O I：

10.1016/j.bmcl.2004.05.066

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 4-arylpiperazin-1-yl-3-phenyloxazolidin-2-one derivatives with diversification of the N-substituents such as methylene O-linked heterocycles, thioamide, dithiocarbamate, thiourea, and thiocarbamate were synthesized and evaluated as antibacterial agents. Their in vitro activities (MIC) were evaluated against MRSA and VRE resistant Gram-positive strains such as Staphylococcus and Enterococcus. Most of the compounds were more potent in vitro but less active in vivo than linezolid. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：3881 / 3883

页数：3

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