The gene encoding thioredoxin-interacting protein (TXNIP) is a frequent virus integration site in virus-induced mouse leukemia and is overexpressed in a subset of AML patients

被引：35

作者：

Erkeland, Stefan J. ^{[1
]}

Palande, Karishma K. ^{[1
]}

Valkhof, Marijke ^{[1
]}

Gits, Judith ^{[1
]}

Danen-van Oorschot, Astrid ^{[1
]}

Touw, Ivo P. ^{[1
]}

机构：

[1] Erasmus Univ, Med Ctr, Dept Hematol, Rotterdam, Netherlands

来源：

LEUKEMIA RESEARCH | 2009年 / 33卷 / 10期

关键词：

Murine leukemia virus; Common virus integration; TXNIP; Redox signaling; Acute myeloid leukemia; UP-REGULATED PROTEIN-1; ACUTE MYELOID-LEUKEMIA; OXIDATIVE STRESS; EXPRESSION; IDENTIFICATION; SYSTEM;

D O I：

10.1016/j.leukres.2009.02.027

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Thioredoxin-interacting protein (TXNIP) is involved in reactive oxygen species-induced stress responses. In a screen for novel disease genes in murine leukemia virus (MLV)-induced mouse leukemias, we identified Txnip as a frequent target for proviral integration. Ectopic TXNIP expression inhibited the proliferation of myeloid progenitor cells. TXNIP transcript and protein levels were significantly elevated in human AML blasts of certain patients, particularly those harboring translocation t(8:21). Nucleotide sequencing revealed no abnormalities in the TXNIP coding region in AML These findings suggest that deregulated TXNIP expression contributes to MLV-induced murine leukemia as well as human AML. (c) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1367 / 1371

页数：5

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