Developmental genomic approaches in model organisms

被引:24
作者
Reinke, V [1 ]
White, KP [1 ]
机构
[1] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06520 USA
关键词
functional genomics; microarrays; development; Caenorhabditis elegans; Drosophila; mouse; genetic networks; computational biology;
D O I
10.1146/annurev.genom.3.031302.100922
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Functional genomics technologies can help decipher how information encoded in the genome is translated into morphology, physiology, and behavior during the development of complex organisms. A number of researchers have begun to apply DNA microarrays and other functional genomics approaches to study development. Here we review recent studies that take the first steps toward relating genome-wide information to developmental events, we discuss recent genomics approaches taken in animal model systems used to study human disease, and we outline methods that may be useful for constructing genome-wide maps of developmental processes.
引用
收藏
页码:153 / 178
页数:30
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