The ABC's (and XYZ's) of peptide sequencing

被引：741

作者：

Steen, H

Mann, M

机构：

[1] Univ So Denmark, Dept Biochem & Mol Biol, DK-5230 Odense M, Denmark

[2] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 09期

关键词：

D O I：

10.1038/nrm1468

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Proteomics is an increasingly powerful and indispensable technology in molecular cell biology. It can be used to identify the components of small protein complexes and large organelles, to determine post-translational modifications and in sophisticated functional screens. The key-but little understood-technology in mass-spectrometry-based proteomics is peptide sequencing, which we describe and review here in an easily accessible format.

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收藏

页码：699 / 711

页数：13

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