Genomic imprinting in the placenta

被引：99

作者：

Wagschal, A.

Feil, R.

机构：

[1] CNRS, Inst Mol Genet, UMR 5535, IGMM, F-34293 Montpellier 5, France

[2] Univ Montpellier 2, F-34095 Montpellier 5, France

来源：

CYTOGENETIC AND GENOME RESEARCH | 2006年 / 113卷 / 1-4期

关键词：

D O I：

10.1159/000090819

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Genomic imprinting is an epigenetic mechanism that is important for the development and function of the extra-embryonic tissues in the mouse. Remarkably all the autosomal genes which were found to be imprinted in the trophoblast (placenta) only are active on the maternal and repressed on the paternal allele. It was shown for several of these genes that their paternal silencing is not dependent on DNA methylation, at least not in its somatic maintenance. Rather, recent studies in the mouse suggest that placenta-specific imprinting involves repressive histone modifications and non-coding RNAs. This mechanism of autosomal imprinting is similar to imprinted X chromosome inactivation in the placenta. Although the underlying reasons remain to be explored, this suggests that imprinting in the placenta and imprinted X inactivation are evolutionarily related. Copyright (c) 2006 S. Karger AG, Basel.

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收藏

页码：90 / 98

页数：9

相关论文

共 99 条

[21] Ring1b-mediated H2A ubiquitination associates with inactive X chromosomes and is involved in initiation of X inactivation [J].

Fang, J ;

Chen, TP ;

Chadwick, B ;

Li, E ;

Zhang, Y .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (51) :52812-52815

[22] Genomic imprinting in ruminants: allele-specific gene expression in parthenogenetic sheep [J].

Feil, R ;

Khosla, S ;

Cappai, P ;

Loi, P .

MAMMALIAN GENOME, 1998, 9 (10) :831-834

[23] Imprinting and the epigenetic asymmetry between parental genomes [J].

Ferguson-Smith, AC ;

Surani, MA .

SCIENCE, 2001, 293 (5532) :1086-1089

[24] Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1 [J].

Fitzpatrick, GV ;

Soloway, PD ;

Higgins, MJ .

NATURE GENETICS, 2002, 32 (03) :426-431

[25] Placental overgrowth in mice lacking the imprinted gene lpl [J].

Frank, D ;

Fortino, W ;

Clark, L ;

Musalo, R ;

Wang, WX ;

Saxena, A ;

Li, CM ;

Reik, W ;

Ludwig, T ;

Tycko, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (11) :7490-7495

[26] Roles for genomic imprinting and the zygotic genome in placental development [J].

Georgiades, P ;

Watkins, M ;

Burton, GJ ;

Ferguson-Smith, AC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (08) :4522-4527

[27] ALLELE-SPECIFIC INACTIVATION OF INSULIN-1 AND INSULIN-2, IN THE MOUSE YOLK-SAC, INDICATES IMPRINTING [J].

GIDDINGS, SJ ;

KING, CD ;

HARMAN, KW ;

FLOOD, JF ;

CARNAGHI, LR .

NATURE GENETICS, 1994, 6 (03) :310-313

[28] Genomic imprinting, development and disease - is pre-eclampsia caused by a maternally imprinted gene? [J].

Graves, JAM .

REPRODUCTION FERTILITY AND DEVELOPMENT, 1998, 10 (01) :23-29

[29] GENOMIC IMPRINTING OF MASH2, A MOUSE GENE REQUIRED FOR TROPHOBLAST DEVELOPMENT [J].

GUILLEMOT, F ;

CASPARY, T ;

TILGHMAN, SM ;

COPELAND, NG ;

GILBERT, DJ ;

JENKINS, NA ;

ANDERSON, DJ ;

JOYNER, AL ;

ROSSANT, J ;

NAGY, A .

NATURE GENETICS, 1995, 9 (03) :235-242

[30]

Hagemann LJ, 1998, MOL REPROD DEV, V50, P154, DOI 10.1002/(SICI)1098-2795(199806)50:2&lt

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