Automatic algorithm for skin profile detection in photoacoustic microscopy

被引:30
作者
Zhang, Hao F. [1 ]
Maslov, Konstantin [1 ]
Wang, Lihong V. [1 ]
机构
[1] Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA
基金
美国国家卫生研究院;
关键词
image processing; photoacoustic microscopy; smoothing; LOCALLY WEIGHTED REGRESSION; VESSELS;
D O I
10.1117/1.3122362
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We have developed an automatic algorithm to detect the skin profiles in the volumetric data acquired by photoacoustic microscopy for subcutaneous vasculature imaging. This algorithm analyzes the relationship between amplitudes of photoacoustic signals generated from the skin surface and underlying blood vessels to achieve a rough estimation of the skin profile. A better approximation of the skin profile is then acquired after nonparametric smoothing and Gaussian low-pass spatial filtering. An auto-fit scan mechanism is further developed based on the detected skin profile to achieve good ultrasonic focusing on the subcutaneous vessel layer when the skin contour variation is much larger than the ultrasonic focal zone. The importance of skin profile detection in calculating the maximum-amplitude-projection images and significantly improving the image quality by employing the auto-fit scan are demonstrated by in vivo experimental results. (C) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3122362]
引用
收藏
页数:6
相关论文
共 24 条
[1]   ARTIFACTS IN MAXIMUM-INTENSITY-PROJECTION DISPLAY OF MR ANGIOGRAMS [J].
ANDERSON, CM ;
SALONER, D ;
TSURUDA, JS ;
SHAPEERO, LG ;
LEE, RE .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1990, 154 (03) :623-629
[2]  
[Anonymous], [No title captured]
[3]  
[Anonymous], 2003, BIOMEDICAL PHOTONICS
[4]  
[Anonymous], 1996, Smooting Methods in Statistics
[5]   Gaussian-based edge-detection methods - A survey [J].
Basu, M .
IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS PART C-APPLICATIONS AND REVIEWS, 2002, 32 (03) :252-260
[6]   Mathematical modeling of tumor-induced angiogenesis [J].
Chaplain, M. A. J. ;
McDougall, S. R. ;
Anderson, A. R. A. .
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 2006, 8 :233-257
[7]   ROBUST LOCALLY WEIGHTED REGRESSION AND SMOOTHING SCATTERPLOTS [J].
CLEVELAND, WS .
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1979, 74 (368) :829-836
[8]   LOCALLY WEIGHTED REGRESSION - AN APPROACH TO REGRESSION-ANALYSIS BY LOCAL FITTING [J].
CLEVELAND, WS ;
DEVLIN, SJ .
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1988, 83 (403) :596-610
[9]  
Frangi AF, 1998, LECT NOTES COMPUT SC, V1496, P130, DOI 10.1007/BFb0056195
[10]   Three-dimensional photoacoustic imaging of blood vessels in tissue [J].
Hoelen, CGA ;
de Mul, FFM ;
Pongers, R ;
Dekker, A .
OPTICS LETTERS, 1998, 23 (08) :648-650