Genome features of Leptospira interrogans serovar Copenhageni

被引：175

作者：

Nascimento, ALTO

Verjovski-Almeida, S

Van Sluys, MA

Monteiro-Vitorello, CB

Camargo, LEA

Digiampietri, LA

Harstkeerl, RA

Ho, PL

Marques, MV

Oliveira, MC

Setubal, JC

Haake, DA

Martins, EAL

机构：

[1] Inst Butantan, Ctr Biotecnol, BR-05503900 Sao Paulo, Brazil

[2] Univ Sao Paulo, Inst Quim, BR-05508 Sao Paulo, Brazil

[3] Univ Sao Paulo, Inst Biociencias, BR-05508 Sao Paulo, Brazil

[4] Univ Sao Paulo, Inst Ciencias Biomed, BR-05508 Sao Paulo, Brazil

[5] Univ Sao Paulo, Escola Super Agr Luiz Queiroz, Piracicaba, SP, Brazil

[6] Univ Estadual Campinas, Inst Computacao, Lab Bioinformat, Campinas, SP, Brazil

[7] Royal Trop Inst, KIT Biomed Res, NL-1105 AZ Amsterdam, Netherlands

[8] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90024 USA

[9] Vet Affairs Greater Los Angeles Healthcare Syst, Div Infect Dis, Los Angeles, CA USA

[10] Virginia Polytech Inst & State Univ, Virginia Bioinformat Inst, Blacksburg, VA 24061 USA

[11] Virginia Polytech Inst & State Univ, Dept Comp Sci, Blacksburg, VA 24061 USA

来源：

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH | 2004年 / 37卷 / 04期

关键词：

Leptospira interrogans; outer membrane proteins; lipopolysaccharides; transport; regulatory systems;

D O I：

10.1590/S0100-879X2004000400003

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We report novel features of the genome sequence of Leptospira interrogans serovar Copenhageni, a highly invasive spirochete. Leptospira species colonize a significant proportion of rodent populations worldwide and produce life-threatening infections in mammals. Genomic sequence analysis reveals the presence of a competent transport system with 13 families of genes encoding for major transporters including a three-member component efflux system compatible with the long-term survival of this organism. The leptospiral genome contains a broad array of genes encoding regulatory system, signal transduction and methyl-accepting chemotaxis proteins, reflecting the organism's ability to respond to diverse environmental stimuli. The identification of a complete set of genes encoding the enzymes for the cobalamin biosynthetic pathway and the novel coding genes related to lipopolysaccharide biosynthesis should bring new light to the study of Leptospira physiology. Genes related to toxins, lipoproteins and several surface-exposed proteins may facilitate a better understanding of the Leptospira pathogenesis and may serve as potential candidates for vaccine.

引用

页码：459 / 478

页数：24

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