The road less traveled:: transport of Legionella to the endoplasmic reticulum

被引：95

作者：

Roy, CR

Tilney, LG

机构：

[1] Yale Univ, Sch Med, Boyer Ctr Mol Med, Sect Microbial Pathogenesis, New Haven, CT 06536 USA

[2] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA

来源：

JOURNAL OF CELL BIOLOGY | 2002年 / 158卷 / 03期

关键词：

phagosome lysosome fusion; ADP ribosylation factor; type IV secretion; immune evasion; intracellular replication;

D O I：

10.1083/jcb.200205011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Phagosomes containing the bacterial pathogen Legionella pneumophila are transported to the ER after macrophage internalization. To modulate phagosome transport, Legionella use a specialized secretion system that injects bacterial proteins into eukaryotic cells. This review will focus on recent studies that have identified bacterial proteins and host processes that play a concerted role in transporting Legionella to the ER.

引用

收藏

页码：415 / 419

页数：5

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