Role of chemokines in glomerular diseases

被引：15

作者：

Banas, B

Wenzel, U

Stahl, RAK

Schlondorff, D

机构：

[1] UNIV MUNICH,KLINIKUM INNENSTADT,MED POLIKLIN,D-80336 MUNICH,GERMANY

[2] UNIV HAMBURG,KRANKENHAUS EPPENDORF,MED KLIN,ABT NEPHROL OSTEOL,D-2000 HAMBURG,GERMANY

来源：

KIDNEY & BLOOD PRESSURE RESEARCH | 1996年 / 19卷 / 05期

关键词：

chemokines; chemotactic factor; glomerular disease; glomerulonephritis;

D O I：

10.1159/000174087

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Various immunological and nonimmunological glomerular diseases were found to be associated with an influx of leukocytes into the diseased kidney Chemotactic factors are likely to play an important role in determining the characteristic cellular infiltration. The human superfamily of chemoattractant cytokines-so-called chemokines-comprises over 20 members which show different properties in targeting specific subpopulations of leukocytes. Expression and effects of chemokines in renal cell culture, animal models of kidney diseases, and human Chemotactic factor glomerular diseases are reviewed. A better knowledge of chemokine action and regulation during glomerular inflammation may help to explore new therapeutic strategies in the future.

引用

页码：270 / 280

页数：11

共 89 条

[1]

ALAM R, 1993, J IMMUNOL, V150, P3442

[2] CC CKRS: A RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophage-tropic HIV-1 [J].