Pathologic changes during acute Q fever: Influence of the route of infection and inoculum size in infected guinea pigs

被引：48

作者：

LaScola, B ^{[1
]}

Lepidi, H ^{[1
]}

Raoult, D ^{[1
]}

机构：

[1] UNIV MEDITERRANNEE, FAC MED, UPRESA 6020, UNITE RICKETTSIES, F-13385 MARSEILLE 05, FRANCE

来源：

INFECTION AND IMMUNITY | 1997年 / 65卷 / 06期

关键词：

D O I：

10.1128/IAI.65.6.2443-2447.1997

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

As assessed by both standard histological staining and immunochemistry, intraperitoneal inoculation of C. burnetii in guinea pigs led to pathologic changes mainly in the liver, whereas intranasal inoculation led to pathologic changes mainly in the lungs. Myocarditis and positive blood cultures were observed only in those animals which received the highest inoculum. We therefore conclude that both the route of infection and the size of the inoculum influence clinical expression in acute Q fever.

引用

页码：2443 / 2447

页数：5

共 20 条

[1] SEROLOGIC ANALYSIS OF A PENITENTIARY GROUP USING RAW-MILK FROM A Q-FEVER INFECTED HERD [J].

BENSON, WW ;

BROCK, DW ;

MATHER, J .

PUBLIC HEALTH REPORTS, 1963, 78 (08) :707-710

[2] Q FEVER HEPATITIS [J].

DUPONT, HL ;

HORNICK, RB ;

LEVIN, HS ;

RAPOPORT, MI ;

WOODWARD, TE .

ANNALS OF INTERNAL MEDICINE, 1971, 74 (02) :198-+

[3] Q-FEVER SEROLOGY - CUTOFF DETERMINATION FOR MICROIMMUNOFLUORESCENCE [J].

DUPONT, HT ;

THIRION, X ;

RAOULT, D .

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 1994, 1 (02) :189-196

[4] EPIDEMIOLOGIC FEATURES AND CLINICAL PRESENTATION OF ACUTE Q-FEVER IN HOSPITALIZED-PATIENTS - 323 FRENCH CASES [J].

DUPONT, HT ;

RAOULT, D ;

BROUQUI, P ;

JANBON, F ;

PEYRAMOND, D ;

WEILLER, PJ ;

CHICHEPORTICHE, C ;

NEZRI, M ;

POIRIER, R .

AMERICAN JOURNAL OF MEDICINE, 1992, 93 (04) :427-434

[5]

DUPUIS G, 1985, SCHWEIZ MED WSCHR, V115, P814

[6] A CLUSTER OF COXIELLA-BURNETII INFECTIONS ASSOCIATED WITH EXPOSURE TO VACCINATED GOATS AND THEIR UNPASTEURIZED DAIRY-PRODUCTS [J].

FISHBEIN, DB ;

RAOULT, D .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1992, 47 (01) :35-40

[7]

GERSTL B, 1956, GASTROENTEROLOGY, V30, P813

[8] CYNOMOLGUS MONKEY MODEL FOR EXPERIMENTAL Q-FEVER INFECTION [J].

GONDER, JC ;

KISHIMOTO, RA ;

KASTELLO, MD ;

PEDERSEN, CE ;

LARSON, EW .

JOURNAL OF INFECTIOUS DISEASES, 1979, 139 (02) :191-196

[9]

HOFMANN CE, 1982, GASTROENTEROLOGY, V83, P474

[10]

KHAVKIN T, 1991, Q FEVER, V1, P71

← 1 2 →