Cell Stress and Aging: New Emphasis on Multiplex Resistance Mechanisms

被引：58

作者：

Miller, Richard A. ^{[1
,2
,3
]}

机构：

[1] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Geriatr Ctr, Ann Arbor, MI 48109 USA

[3] Ann Arbor VA Med Ctr, Ann Arbor, MI USA

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2009年 / 64卷 / 02期

关键词：

Longevity; Cell injury; Overview; Comparative biology; LIFE-SPAN; FIBROBLASTS; LONGEVITY; FORMS;

D O I：

10.1093/gerona/gln072

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Work, initially in Caenorhabditis elegans and then more recently in fruit flies and mice, has suggested that anti-aging mutations extend life span by simultaneous activation of pathways that protect cells from multiple forms of injury. This "multiplex stress resistance" theory suggests a number of new avenues for investigation of the genetic and cellular controls that influence organismic longevity within and among species, and that might lead to the development of pharmaceuticals that retard the aging process and, therefore, the entire panoply of age-dependent diseases and disabilities.

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页码：179 / 182

页数：4

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