B cells as antigen presenting cells

被引:221
作者
Rodríguez-Pinto, D [1 ]
机构
[1] Yale Univ, Sch Med, Endocrinol Sect, Dept Internal Med, New Haven, CT 06520 USA
关键词
B cells; antigen presentation; BCR; autoimmunity;
D O I
10.1016/j.cellimm.2006.02.005
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Several characteristics confer on B cells the ability to present antigen efficiently: (1) they can find T cells in secondary lymphoid organs shortly after antigen entrance, (2) BCR-mediated endocytosis allows them to concentrate small amounts of specific antigen, and (3) BCR signaling and HLA-DO expression direct their antigen processing machinery to favor presentation of antigens internalized through the BCR. When presenting antigen in a resting state, B cells can induce T cell tolerance. On the other hand, activation by antigen and T cell help converts them into APC capable of promoting immune responses. Presentation of self antigens by B cells is important in the development or autoimmune diseases, while presentation of tumor antigens is being used in vaccine strategies to generate immunity. Thus, detailed understanding of the antigen presenting function or B cells can lead to their use for the generation or inhibition Of immune responses. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:67 / 75
页数:9
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