NADPH oxidases: New kids on the block

被引：170

作者：

Geiszt, Miklos ^{[1
]}

机构：

[1] Semmelweis Univ, Fac Med, Dept Physiol, H-1444 Budapest, Hungary

来源：

CARDIOVASCULAR RESEARCH | 2006年 / 71卷 / 02期

基金：

英国惠康基金;

关键词：

NADPH oxidase; Nox; duox; superoxide; reactive oxygen species (ROS);

D O I：

10.1016/j.cardiores.2006.05.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Reactive oxygen species (ROS) play a pivotal role in many physiological processes including host defense, hormone biosynthesis, fertilization and cellular signaling. Altered production of ROS has been implicated in the development of immunodeficiency, hypothyroidism and cardiovascular pathologies. In the last few years, several enzymes were identified at the molecular level, which are now thought to be responsible for ROS production observed in diverse tissues. These enzymes show a high degree of homology to the phagocytic NADPH oxidase and are now designated the Nox family of NADPH oxidases. This review updates our knowledge on six new members of the Nox family: Nox1, Nox3, Nox4, Nox5, Duox1 and Duox2. (c) 2006 European Society of Cardiology. Published by Elsevier B.V All rights reserved.

引用

页码：289 / 299

页数：11

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