Continuous perfusion with morphine of the orbitofrontal cortex reduces allodynia and hyperalgesia in a rat model for mononeuropathy

被引：16

作者：

Al Amin, HA

Atweh, SF

Baki, SA

Jabbur, SJ

Saadé, NE

机构：

[1] Amer Univ Beirut, Dept Human Morphol, Fac Med, Beirut 11072020, Lebanon

[2] Amer Univ Beirut, Dept Physiol, Fac Med, Beirut, Lebanon

[3] Amer Univ Beirut, Dept Psychiat, Fac Med, Beirut, Lebanon

[4] Amer Univ Beirut, Dept Internal Med, Fac Med, Beirut, Lebanon

来源：

NEUROSCIENCE LETTERS | 2004年 / 364卷 / 01期

关键词：

opiates; nociception; prefrontal cortex; pain modulation; chronic pain; pain tests; plasticity; orbital area;

D O I：

10.1016/j.neulet.2004.04.017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent imaging reports demonstrate the activation of the orbitofrontal cortical (OFC) area during acute and chronic pain. The aim of this study was to compare the effects of chronic perfusion of this area with morphine on nociception in control rats and in rats subjected to mononeuropathy. Chronic perfusion of morphine, using miniosmotic pumps, produced significant and naloxone-reversible depression of tactile and cold allodynias and thermal hyperalgesia, observed in neuropathic rats, while it produced significant elevation and naloxone insensitive increase of acute nociceptive thresholds in control rats. The observed results support the idea that this area is a component of a flexible cerebral network involved in pain processing and perception. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：27 / 31

页数：5

共 23 条

[21] EVIDENCE FOR INVOLVEMENT OF THE FRONTAL-CORTEX IN PAIN-RELATED CEREBRAL EVENTS IN CATS - INCREASE IN LOCAL CEREBRAL BLOOD-FLOW BY NOXIOUS STIMULI [J].