Brassicaceae contain nortropane alkaloids

被引:55
作者
Brock, Andrea
Herzfeld, Tobias
Paschke, Reinhard
Koch, Marcus
Draeger, Birgit
机构
[1] Univ Halle Wittenberg, Fac Pharm, Inst Pharmaceut Biol & Pharmacol, D-06120 Halle, Germany
[2] Univ Halle Wittenberg, Bioctr, D-06120 Halle, Germany
[3] Univ Heidelberg, Heidelberg Inst Plant Sci, D-69120 Heidelberg, Germany
关键词
Cochlearia officinalis; Brassicaceae; calystegine; cochlearine; tropane alkaloid;
D O I
10.1016/j.phytochem.2006.06.024
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The report of cochlearine, the 3-hydroxybenzoate ester of tropine found in Cochlearia officinalis, Brassicaceae, initiated a screening for tropane alkaloids in Cochlearia species and for calystegines in further Brassicaceae. All ten Cochlearia species investigated contained cochlearine, tropine, and pseudotropine. Calystegines, nortropane alkaloids deriving from pseudotropine, were also identified in all Cochlearia species and accumulated up to 0.5% dry mass in leaves. Brassicaceae species of all major lineages of the family were analysed for calystegines. Of the 43 species included in the study, 18 accumulated calystegines of various structures. This is the first screening of Brassicaceae for products of the tropane alkaloid pathway, which is known as characteristic for plants of Solanaceae family. The identification of calystegines in all branches of the Brassicaceae family including Aethionema, a species at the basis of the family, suggests tropane alkaloids as secondary compound typical for Brassicaceae. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2050 / 2057
页数:8
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