GeneWays:: a system for extracting, analyzing, visualizing, and integrating molecular pathway data

被引:174
作者
Rzhetsky, A [1 ]
Iossifov, I
Koike, T
Krauthammer, M
Kra, P
Morris, M
Yu, H
Duboué, PA
Weng, WB
Wilbur, WJ
Hatzivassiloglou, V
Friedman, C
机构
[1] Columbia Univ, Columbia Genome Ctr, New York, NY 10032 USA
[2] Columbia Univ, Dept Biomed Informat, New York, NY 10032 USA
[3] Columbia Univ, Ctr Computat Biol & Bioinformat, New York, NY 10032 USA
[4] Columbia Univ, Dept Comp Sci, New York, NY 10032 USA
[5] Hitachi Software Engn Co Ltd, Yokohama, Kanagawa, Japan
[6] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20984 USA
关键词
text mining; bioinformatics; information extraction; molecular networks; molecular interactions; database; artificial intelligence; knowledge engineering; machine learning;
D O I
10.1016/j.jbi.2003.10.001
中图分类号
TP39 [计算机的应用];
学科分类号
081203 ; 0835 ;
摘要
The immense growth in the volume of research literature and experimental data in the field of molecular biology calls for efficient automatic methods to capture and store information. In recent years. several groups have worked on specific problems in this area, such as automated selection of articles pertinent to molecular biology. or automated extraction of information using natural-language processing. information visualization. and generation of specialized knowledge bases for molecular biology. GeneWays is an integrated system that combines several such subtasks. It analyzes interactions between molecular Substances, drawing on multiple Sources of information to infer a consensus view of molecular networks. GeneWays is designed as an open platform, allowing researchers to query. review. and critique stored information. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码:43 / 53
页数:11
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