Long non-coding RNAs: insights into functions

被引：4793

作者：

Mercer, Tim R. ^{[1
]}

Dinger, Marcel E. ^{[1
]}

Mattick, John S. ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, Australian Res Council, Special Res Ctr Funct & Appl Gen, Brisbane, Qld 4072, Australia

来源：

NATURE REVIEWS GENETICS | 2009年 / 10卷 / 03期

基金：

澳大利亚研究理事会;

关键词：

MESSENGER-RNA; TRANSCRIPTION INITIATION; ANTISENSE TRANSCRIPT; HUMAN-CELLS; GENE; CHROMATIN; EVOLUTION; REGIONS; DIFFERENTIATION; ARCHITECTURE;

D O I：

10.1038/nrg2521

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In mammals and other eukaryotes most of the genome is transcribed in a developmentally regulated manner to produce large numbers of long non-coding RNAs (ncRNAs). Here we review the rapidly advancing field of long ncRNAs, describing their conservation, their organization in the genome and their roles in gene regulation. We also consider the medical implications, and the emerging recognition that any transcript, regardless of coding potential, can have an intrinsic function as an RNA.

引用

页码：155 / 159

页数：5

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