A short diastereoselective synthesis of 1-aminoindolo-[2,3-a]quinolizidines via an N-acyliminium ion cyclisation

被引：21

作者：

Ducrot, P ^{[1
]}

Thal, C ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 51期

关键词：

D O I：

10.1016/S0040-4039(99)01922-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

trans 1-Aminoindolo[2,3-a]quinolizidines were synthesised using an intramolecular Pictet-Spengler-like reaction. Starting from commercially available N-Cbz-L-glutamic acid, indoloquinolizidines were obtained in only five steps with good yields. This improved synthesis is the result of both a highly regioselective imide reduction and a highly diastereoselective reaction using N-acyliminium ions. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：9037 / 9040

页数：4

共 13 条

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