Recurrent seizures in metachromatic leukodystrophy

The unusual presentation of juvenile onset metachromatic leukodystrophy (MLD) and frequent complex partial seizures in a patient led us to perform a retrospective study of 18 patients with MLD to identify the prevalence and type of recurrent seizures during the first 2 years of the disease, Five of 17 patients (29%) had developed recurrent seizures within 12 months of the onset of symptoms, and one patient was lost to follow-up, By 24 months after onset of symptoms, 5 patients were lost to follow-up, and 6 of the remaining 13 patients (46%) had developed recurrent seizures, In all, 7 patients, 4 with late infantile-onset and 3 with juvenile-onset disease, developed recurrent seizures, Four patients, including 3 with juvenile-onset disease had complex partial seizures, We conclude that recurrent seizures are common in MLD and may occur at any stage of the disease, particularly in patients with juvenile onset, Generalized seizures are more frequent in patients with late infantile-onset, whereas partial seizures are more common in those with juvenile-onset disease, (C) 1997 by Elsevier Science Inc, All rights reserved.