Brain volume changes in the first year of illness and 5-year outcome of schizophrenia

被引：101

作者：

Cahn, W. ^{[1
]}

van Haren, N. E. M. ^{[1
]}

Pol, H. E. Hulshoff ^{[1
]}

Schnack, H. G. ^{[1
]}

Caspers, E. ^{[1
]}

Laponder, D. A. J. ^{[1
]}

Kahn, R. S. ^{[1
]}

机构：

[1] Univ Utrecht, Med Ctr, Dept Psychiat, Rudolf Magnus Inst Neurosci, NL-3584 GX Utrecht, Netherlands

来源：

BRITISH JOURNAL OF PSYCHIATRY | 2006年 / 189卷

关键词：

D O I：

10.1192/bjp.bp.105.015701

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Progressive brain volume changes have been reported in first-episode schizophrenia, but their relationship to the disease process or to other factors remains unclear. We examined such changes in the first year of illness, and related them to 5-year outcome. Progressive brain volume changes, in particular of grey matter, during the first year of illness were found to be significantly associated with clinical and functional outcome 5 years after the first episode. These findings suggest that early dynamic brain volume changes are related to the disease process and predict the longer-term outcome of schizophrenia.

引用

页码：381 / 382

页数：2

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