Animal models of rheumatoid arthritis

被引：261

作者：

Asquith, Darren L. ^{[1
]}

Miller, Ashley M. ^{[1
]}

McInnes, Iain B. ^{[1
]}

Liew, Foo Y. ^{[1
]}

机构：

[1] Univ Glasgow, Div Immunol Infect & Inflammat, Glasgow Biomed Res Ctr, Glasgow G12 8TA, Lanark, Scotland

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2009年 / 39卷 / 08期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

Animal; Arthritis; Collagen; Model; Rheumatoid; COLLAGEN-INDUCED ARTHRITIS; ANTIBODY-INDUCED ARTHRITIS; ANTIGEN-INDUCED ARTHRITIS; ZYMOSAN-INDUCED ARTHRITIS; T-CELLS; GLUCOSE-6-PHOSPHATE ISOMERASE; AUTOIMMUNE ARTHRITIS; MONOCLONAL-ANTIBODY; ADJUVANT ARTHRITIS; SELF-TOLERANCE;

D O I：

10.1002/eji.200939578

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Animal models have been used extensively in studies of rheumatoid arthritis pathogenesis. Despite the inherent limitations of all animal models, several rodent models have significantly progressed our understanding of the fundamental mechanisms underpinning rheumatoid arthritis and contributed to several current major advances in treatment. These models include the induced arthritis models such as collagen-induced arthritis, collagen-antibody-induced arthritis, zymosan-induced arthritis, and the methylated BSA model, and the genetically manipulated or spontaneous arthritis models such as the TNF-alpha-transgenic mouse, K/BxN mouse, and the Skg mouse. Here, we describe these animal models and discuss their advantages and limitations.

引用

页码：2040 / 2044

页数：5

共 43 条

[1] EXPERIMENTAL IMMUNE MEDIATED ARTHRITIS IN RHESUS-MONKEYS - A MODEL FOR HUMAN RHEUMATOID-ARTHRITIS [J].

BAKKER, NPM ;

VANERCK, MG ;

ZURCHER, C ;

FAABER, P ;

LEMMENS, A ;

HAZENBERG, M ;

BONTROP, RE ;

JONKER, M .

RHEUMATOLOGY INTERNATIONAL, 1990, 10 (01) :21-29

[2]

BRACKERTZ D, 1977, J IMMUNOL, V118, P1639

[3] ANTIGEN-INDUCED ARTHRITIS IN MICE .1. INDUCTION OF ARTHRITIS IN VARIOUS STRAINS OF MICE [J].

BRACKERTZ, D ;

MITCHELL, GF ;

MACKAY, IR .

ARTHRITIS AND RHEUMATISM, 1977, 20 (03) :841-850

[4] Immunopathogenesis of collagen arthritis [J].

Brand, DD ;

Kang, AH ;

Rosloniec, EF .

SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 2003, 25 (01) :3-18

[5]

Campbell IK, 2000, EUR J IMMUNOL, V30, P1568, DOI 10.1002/1521-4141(200006)30:6<1568::AID-IMMU1568>3.0.CO

[6]

2-R

[7] Interpreting lipid levels in the context of high-grade inflammatory states with a focus on rheumatoid arthritis: a challenge to conventional cardiovascular risk actions [J].

Choy, E. ;

Sattar, N. .

ANNALS OF THE RHEUMATIC DISEASES, 2009, 68 (04) :460-469

[8] IMMUNIZATION AGAINST HETEROLOGOUS TYPE-II COLLAGEN INDUCES ARTHRITIS IN MICE [J].

COURTENAY, JS ;

DALLMAN, MJ ;

DAYAN, AD ;

MARTIN, A ;

MOSEDALE, B .

NATURE, 1980, 283 (5748) :666-668

[9] Humanized mice as a model for rheumatoid arthritis [J].

Eming, Ruediger ;

Visconti, Kevin ;

Hall, Frances ;

Sekine, Chiyoko ;

Kobayashi, Kayta ;

Chen, Qun ;

Cope, Andrew ;

Kanazawa, Satoshi ;

Peterlin, Matija ;

Rijnders, Antonius ;

Boots, Annemieke ;

Meijerink, Jan ;

Sonderstrup, Grete .

ARTHRITIS RESEARCH & THERAPY, 2002, 4 (Suppl 3) :S133-S140

[10] TLR2 modulates inflammation in zymosan-induced arthritis in mice [J].

Frasnelli, ME ;

Tarussio, D ;

Chobaz-Péclat, V ;

Busso, N ;

So, A .

ARTHRITIS RESEARCH & THERAPY, 2005, 7 (02) :R370-R379

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