EXPERIMENTAL IMMUNE MEDIATED ARTHRITIS IN RHESUS-MONKEYS - A MODEL FOR HUMAN RHEUMATOID-ARTHRITIS

被引：37

作者：

BAKKER, NPM

VANERCK, MG

ZURCHER, C

FAABER, P

LEMMENS, A

HAZENBERG, M

BONTROP, RE

JONKER, M

机构：

[1] ERASMUS UNIV,DEPT IMMUNOL,3000 DR ROTTERDAM,NETHERLANDS

[2] TNO,IVEG INST,2280 HV RIJSWIJK,NETHERLANDS

[3] CATHOLIC UNIV NIJMEGEN,SINT RADBOUD HOSP,DEPT RHEUMATOL,6525 GA NIJMEGEN,NETHERLANDS

[4] CATHOLIC UNIV NIJMEGEN,SINT RADBOUD HOSP,DEPT RADIOL DIAG,6525 GA NIJMEGEN,NETHERLANDS

来源：

RHEUMATOLOGY INTERNATIONAL | 1990年 / 10卷 / 01期

关键词：

Arthritis; Collagen; Inflammation; Rhesus monkey;

D O I：

10.1007/BF02274777

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The induction of experimental arthritis in rhesus monkeys was studied by intradermal immunization of bovine type II collagen and antigens derived from Mycobacterium tuberculosis, Streptococcus pyogenes, and Eubacterium aerofaciens. The tested bacterial antigens proved to be not arthritogenic. Bovine type II collagen induced clinical arthritis in 50% of the rhesus monkeys. Type II collagen induced arthritis in rhesus monkeys proved to be a potential model to study clinical, serological, histological, genetic, and immunologic features associated with human RA. © 1990 Springer-Verlag.

引用

页码：21 / 29

页数：9

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