Fluorescence imaging of bone cracks (microdamage) using visibly emitting 1,8-naphthalimide-based PET sensors

被引：32

作者：

Parkesh, Raman ^{[1
,2
]}

Lee, T. Clive ^{[2
]}

Gunnlaugsson, Thorfinnur ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Sch Chem, Ctr Synth & Chem Biol, Dublin 2, Ireland

[2] Royal Coll Surgeons Ireland, Dept Anat, Dublin 2, Ireland

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 28期

关键词：

PHOTOINDUCED ELECTRON-TRANSFER; TERBIUM COMPLEXES; SURFACE-ANALYSIS; LUMINESCENT; ANIONS; CHEMOSENSORS; RECOGNITION; GROWTH;

D O I：

10.1016/j.tetlet.2009.04.115

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The ability of two 4-amino-1,8-naphthalimides (1 and 2) and anthracene (3) based photoinduced electron transfer (PET) sensors, previously developed in our laboratory, to function as selective imaging agents for exposed Ca(II) in bone cracks, using fluorescence microscopy imaging is described. While the emission from 3 is masked by the autofluorescence arising from the (bovine) bone matrix, both I and 2, emitting in the green, are able to clearly identify areas of damaged bone. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：4114 / 4116

页数：3

共 42 条

[1] Sol gel-immobilised terbium complexes for luminescent sensing of dissolved oxygen by analysis of emission decay [J].

Blair, S ;

Kataky, R ;

Parker, D .

NEW JOURNAL OF CHEMISTRY, 2002, 26 (05) :530-535

[2] Narrow-range optical pH sensors based on luminescent europium and terbium complexes immobilized in a sol gel glass [J].

Blair, S ;

Lowe, MP ;

Mathieu, CE ;

Parker, D ;

Senanayake, PK ;

Kataky, R .

INORGANIC CHEMISTRY, 2001, 40 (23) :5860-5867

[3]

de Silva AP, 1998, TETRAHEDRON LETT, V39, P5077

[4] Signaling recognition events with fluorescent sensors and switches [J].

de Silva, AP ;

Gunaratne, HQN ;

Gunnlaugsson, T ;

Huxley, AJM ;

McCoy, CP ;

Rademacher, JT ;

Rice, TE .

CHEMICAL REVIEWS, 1997, 97 (05) :1515-1566

[5] Recent developments in the field of supramolecular lanthanide luminescent sensors and self-assemblies [J].

dos Santos, Cidalia M. G. ;

Harte, Andrew J. ;

Quinn, Susan J. ;

Gunnlaugsson, Thorfinnur .

COORDINATION CHEMISTRY REVIEWS, 2008, 252 (23-24) :2512-2527

[6] Colorimetric sensing of anions in aqueous solution using a charge neutral, cleft-like, amidothiourea receptor: tilting the balance between hydrogen bonding and deprotonation in anion recognition [J].

Duke, Rebecca M. ;

O'Brien, John E. ;

McCabe, Thomas ;

Gunnlaugsson, Thorfinnur .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2008, 6 (22) :4089-4092

[7] MICRODAMAGE IN RESPONSE TO REPETITIVE TORSIONAL LOADING IN THE RAT TIBIA [J].

FORWOOD, MR ;

PARKER, AW .

CALCIFIED TISSUE INTERNATIONAL, 1989, 45 (01) :47-53

[8]

FROST HM, 1973, BONE REMODELLING ITS

[9] A switch in a cage with a memory [J].

Giordani, S ;

Raymo, FM .

ORGANIC LETTERS, 2003, 5 (20) :3559-3562

[10] Highly selective fluorescent chemsensors for cadmium in water [J].

Gunnlaugsson, T ;

Lee, TC ;

Parkesh, R .

TETRAHEDRON, 2004, 60 (49) :11239-11249

← 1 2 3 4 5 →