Highways for protein delivery to the mitochondria

被引：52

作者：

Lithgow, T

Cuezva, JM

Silver, PA

机构：

[1] UNIV AUTONOMA MADRID,CTR BIOL MOL,E-28049 MADRID,SPAIN

[2] HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOL PHARMACOL,BOSTON,MA 02115

[3] DANA FARBER CANC INST,BOSTON,MA 02115

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 04期

关键词：

D O I：

10.1016/S0968-0004(97)01007-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Messenger RNA (mRNA) localisation is one of the prime mechanisms to ensure protein localisation in the cytoplasm of polarised embryonic cells, and has been well-studied in the development of Xenopus and Drosophila embryos. But what of other cells? Here, we discuss whether the directed transport of mRNA out of the nucleus, following cytoplasmic highways to a specified organelle in the cytoplasm, might also contribute to the exquisite fidelity of protein targeting observed in all eukaryotic cells.

引用

页码：110 / 113

页数：4

共 30 条

[1] ADES IZ, 1980, J BIOL CHEM, V255, P9918
[2] The yeast Pan2 protein is required for poly(A)-binding protein-stimulated poly(A)-nuclease activity
Boeck, R
Tarun, S
Rieger, M
Deardorff, JA
MullerAuer, S
Sachs, AB
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (01) : 432 - 438
[3] A MUTANT NUCLEAR-PROTEIN WITH SIMILARITY TO RNA-BINDING PROTEINS INTERFERES WITH NUCLEAR IMPORT IN YEAST
BOSSIE, MA
DEHORATIUS, C
BARCELO, G
SILVER, P
[J]. MOLECULAR BIOLOGY OF THE CELL, 1992, 3 (08) : 875 - 893
[4] CARTWRIGHT P, 1997, IN PRESS J BIOL CHEM, V272
[5] EGEA G, IN PRESS BIOCH J
[6] THE SACCHAROMYCES-CEREVISIAE MTS1 GENE ENCODES A PUTATIVE RNA-BINDING PROTEIN INVOLVED IN MITOCHONDRIAL PROTEIN TARGETING
ELLIS, EM
REID, GA
[J]. GENE, 1993, 132 (02) : 175 - 183
[7] A YEAST RNA-BINDING PROTEIN SHUTTLES BETWEEN THE NUCLEUS AND THE CYTOPLASM
FLACH, J
BOSSIE, M
VOGEL, J
CORBETT, A
JINKS, T
WILLINS, DA
SILVER, PA
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (12) : 8399 - 8407
[8] MITOCHONDRIAL PROTEIN IMPORT - ISOLATION AND CHARACTERIZATION OF THE SACCHAROMYCES-CEREVISIAE MFT1 GENE
GARRETT, JM
SINGH, KK
VONDERHAAR, RA
EMR, SD
[J]. MOLECULAR & GENERAL GENETICS, 1991, 225 (03): : 483 - 491
[9] Protein kinesis - Nucleocytoplasmic transport
Gorlich, D
Mattaj, IW
[J]. SCIENCE, 1996, 271 (5255) : 1513 - 1518
[10] ANALYSIS OF THE POLYADENYLATION CONSENSUS SEQUENCE CONTEXT IN THE GENES OF NUCLEAR ENCODED MITOCHONDRIAL PROTEINS
JURETIC, N
THEUS, M
[J]. FEBS LETTERS, 1991, 290 (1-2) : 4 - 8

← 1 2 3 →