Highways for protein delivery to the mitochondria

被引：52

作者：

Lithgow, T

Cuezva, JM

Silver, PA

机构：

[1] UNIV AUTONOMA MADRID,CTR BIOL MOL,E-28049 MADRID,SPAIN

[2] HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOL PHARMACOL,BOSTON,MA 02115

[3] DANA FARBER CANC INST,BOSTON,MA 02115

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 04期

关键词：

D O I：

10.1016/S0968-0004(97)01007-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Messenger RNA (mRNA) localisation is one of the prime mechanisms to ensure protein localisation in the cytoplasm of polarised embryonic cells, and has been well-studied in the development of Xenopus and Drosophila embryos. But what of other cells? Here, we discuss whether the directed transport of mRNA out of the nucleus, following cytoplasmic highways to a specified organelle in the cytoplasm, might also contribute to the exquisite fidelity of protein targeting observed in all eukaryotic cells.

引用

页码：110 / 113

页数：4

共 30 条

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