ADAM12 alleviates the skeletal muscle pathology in mdx dystrophic mice

被引:54
作者
Kronqvist, P
Kawaguchi, N
Albrechtsen, R
Xu, XF
Schroder, HD
Moghadaszadeh, B
Nielsen, FC
Fröhlich, C
Engvall, E
Wewer, UM
机构
[1] Univ Copenhagen, Inst Mol Pathol, DK-2100 Copenhagen, Denmark
[2] Burnham Inst, La Jolla, CA 92037 USA
[3] Odense Univ, Dept Pathol, Odense, Denmark
[4] Copenhagen Univ Hosp, Dept Clin Biochem, Copenhagen, Denmark
基金
美国国家卫生研究院; 日本学术振兴会;
关键词
D O I
10.1016/S0002-9440(10)64431-8
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Muscular dystrophy is characterized by muscle degeneration and insufficient regeneration and replacement of muscle fibers by connective tissue. New therapeutic strategies directed toward various forms of muscular dystrophy are needed to preserve muscle mass and promote regeneration. in this study we examined the role of the transmembrane ADAM12, a disintegrin and metalloprotease, which is normally associated with development and regeneration of skeletal muscle. We demonstrate that ADAM12 overexpression in the dystrophin-deficient mdx mice alleviated the muscle pathology in these animals, as evidenced by less muscle cell necrosis and inflammation, lower levels of serum creatine kinase, and less uptake of Evans Blue dye into muscle fibers. These studies demonstrate that ADAM12 directly or indirectly contributes to muscle cell regeneration, stability, and survival.
引用
收藏
页码:1535 / 1540
页数:6
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