Structural determination of sulfoquinovosyldiacylglycerol by chiral syntheses

被引：48

作者：

Hanashima, S

Mizushina, Y

Yamazaki, T

Ohta, K

Takahashi, S

Koshino, H

Sahara, H

Sakaguchi, K

Sugawara, F ^{[1
]}

机构：

[1] Tokyo Univ Sci, Dept Appl Biol Sci, Noda, Chiba 2788510, Japan

[2] Inst Phys & Chem Res, Wako, Saitama 3519800, Japan

[3] Sapporo Med Univ, Sch Med, Inst Marine Biomed, Rishirifuji, Hokkaido 0970101, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(00)00638-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral sulfoquinovosyldiacylglycerols (SQDGs) have been synthesized to determine the absolute stereochemistry and the biological activities. The H-1 NMR spectrum of a natural SQDG is comparable to that of synthetic (2S)-SQDC rather than that of the (2R) analogue. The biological activity of the respective isomers for DNA polymerase alpha and beta inhibition was not distinguishable in the enzymatic assay. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：4403 / 4407

页数：5

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