Gallstone disease: primary and secondary prevention

被引：29

作者：

Venneman, Niels G. ^{[1
]}

van Erpecum, Karel J.

机构：

[1] Univ Med Ctr Utrecht, Dept Gastroenterol, Gastrointestinal Res Unit, Utrecht, Netherlands

[2] St Antonius Hosp, Dept Internal Med, NL-3430 EM Nieuwegein, Netherlands

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2006年 / 20卷 / 06期

关键词：

acute cholecystitis; acute pancreatitis; choledocholithiasis; gallbladder; gallstone; prevention; UDCA;

D O I：

10.1016/j.bpg.2006.03.008

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Several risk factors for cholesterol gallstone formation in the general population have been identified. There is a strongly increased risk of gallstone disease during prolonged fasting, rapid weight loss, total parenteral nutrition, and somatostati n (-analogue) treatment. The annual risk of biliary colic and gallstone complications in asymptomatic gallstone carriers has been investigated sparsely. In asymptomatic and symptomatic gallstone carriers, treatment with the hydrophilic bile salt ursocleoxycholic acid (UDCA) has been claimed to reduce the risk of biliary colic and gallstone complications such as acute cholecystitis and acute pancreatitis. Also, prophylactic cholecystectomy could be beneficial in certain subgroups of asymptomatic gallstone carriers. However, randomized, double-blind, placebo-controlled trials are lacking. In this review, strategies for the prevention of gallstone formation in the general population and in high-risk conditions are dealt with. Also, strategies for the prevention of biliary colic and gallstone complications in asymptomatic and symptomatic gallstone carriers are discussed.

引用

页码：1063 / 1073

页数：11

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