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Adenovirus-5 E1A: Paradox and paradigm

被引：245
作者：
Frisch, SM
Mymryk, JS
机构：
[1] Burnham Inst, La Jolla, CA 92037 USA
[2] Univ Western Ontario, London Reg Canc Ctr, Dept Oncol, London, ON N6A 4L6, Canada
[3] Univ Western Ontario, London Reg Canc Ctr, Dept Immunol & Microbiol, London, ON N6A 4L6, Canada
[4] Univ Western Ontario, London Reg Canc Ctr, Dept Pharmacol & Toxicol, London, ON N6A 4L6, Canada
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 06期
基金：
加拿大健康研究院;
关键词：
D O I：
10.1038/nrm827
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The adenovirus early region 1A (E1A) proteins were described originally as immortalizing oncoproteins that altered transcription in rodent cells. Surprisingly, the 243-amino-acid form of adenovirus-5E1A was found subsequently to reverse-transform many human tumour cells. Tumour suppression apparently results from the ability of E1A to re-programme transcription in tumour cells, and the molecular basis of this intriguing effect is now beginning to emerge. These discoveries have provided a tool with which to study the regulation of fundamental cellular processes.
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页码：441 / U3
页数：14
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