Adenovirus-5 E1A: Paradox and paradigm

被引：245

作者：

Frisch, SM

Mymryk, JS

机构：

[1] Burnham Inst, La Jolla, CA 92037 USA

[2] Univ Western Ontario, London Reg Canc Ctr, Dept Oncol, London, ON N6A 4L6, Canada

[3] Univ Western Ontario, London Reg Canc Ctr, Dept Immunol & Microbiol, London, ON N6A 4L6, Canada

[4] Univ Western Ontario, London Reg Canc Ctr, Dept Pharmacol & Toxicol, London, ON N6A 4L6, Canada

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 06期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1038/nrm827

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The adenovirus early region 1A (E1A) proteins were described originally as immortalizing oncoproteins that altered transcription in rodent cells. Surprisingly, the 243-amino-acid form of adenovirus-5E1A was found subsequently to reverse-transform many human tumour cells. Tumour suppression apparently results from the ability of E1A to re-programme transcription in tumour cells, and the molecular basis of this intriguing effect is now beginning to emerge. These discoveries have provided a tool with which to study the regulation of fundamental cellular processes.

引用

页码：441 / U3

页数：14

共 146 条

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