Flavones and cytotoxic constituents from the stem bark of Muntingia calabura

被引：24

作者：

Chen, JJ ^{[1
]}

Lin, RW

Duh, CY

Huang, HY

Chen, IS

机构：

[1] Tajen Inst Technol, Dept Pharm, Pingtung 907, Taiwan

[2] Kaohsiung Med Univ, Inst Pharmaceut Sci, Kaohsiung 807, Taiwan

[3] Natl Sun Yat Sen Univ, Inst Marine Resources, Kaohsiung 804, Taiwan

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2004年 / 51卷 / 03期

关键词：

muntingia calabura; Tiliaceae; stem bark; flavones; 8-hydroxy-7,3',4',5'-tetramethoxyflavone; 8,4'-dihydroxy-7,3',5'-trimethoxyflavone; cytotoxicity;

D O I：

10.1002/jccs.200400100

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two new flavones, 8-hydroxy-7,3',4',5'-tetramethoxyflavone and 8,4'-dihydroxy-7,3',5'-trimethoxyflavone, together with thirteen known compounds have been isolated from the stem bark of Muntingia calabura. The structures of two new compounds were determined through spectral analyses. Among the isolates, 8-hydroxy-7,3',4',5'-tetramethoxyflavone, 8,4'-dihydroxy-7,3',5'-trimethoxyflavone, and 3-hydroxy-1-(3,5-dimethoxy-4-hydroxyphenyl)propan-1-one exhibited effective cytotoxicities (ED50 values = 3.56, 3.71, and 3.27 mug/mL, respectively) against the P-388 cell line in vitro.

引用

页码：665 / 670

页数：6

共 15 条

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