Colorectal cancer with non resectable synchronous metastases:: should the primary tumor be resected?

被引:90
作者
Michel, P
Roque, I
Di Fiore, F
Langlois, S
Scotte, M
Tenière, P
Paillot, B
机构
[1] CHU Rouen, Hop Charles Nicolle, Serv Hepatogastroenterol, F-76031 Rouen, France
[2] CHU Rouen, Hop Charles Nicolle, Serv Chirurgie Digest, F-76031 Rouen, France
来源
GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE | 2004年 / 28卷 / 05期
关键词
D O I
10.1016/S0399-8320(04)94952-4
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objectives - In asymptomatic patients presenting with nonresectable synchronous metastatic disease from colorectal adenocarcinoma, the beneficial effect of resecting the primary tumor remains to be documented. The aim of this study was to compare survival of patients with metastatic colorectal cancer who underwent elective resection of the primary tumor to those who did not. Methods - A retrospective analysis of patients with metastatic colo-rectal cancer treated between June, 1996 and December, 1999 was performed. Overall survival was compared between patients who underwent first-line resection of the primary colorectal tumor (group 1) or those who did not undergo elective resection of the primary (group 2). The probability of surgical resection of the primary tumor for gastrointestinal complications in group 2 was evaluated. Results - Thirty-one and 23 patients were included in groups 1 and 2 respectively. Five patients (21.7%, 95% confidence interval Cl-95% 4.9-38.5%) in group 2 required surgical treatment for intestinal obstruction due to the primary tumor. Two clinical characteristics were significantly different between groups 1 and 2: rectal localization (9.7% versus 34.7%; P = 0.03) and presence of fewer than three metastases (29.0% versus 4.3%; P = 0.03). Survival curves were not significantly different (logrank). Median duration of survival was 21 and 14 months, respectively (P = 0.718). Conclusion - In patients with non-resectable synchronous metastatic disease, non-surgical management of the primary tumor is a rational alternative if asymptomatic. A prospective randomized trial integrating the quality-of-life factor should be organized.
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页码:434 / 437
页数:4
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