Perspectives on PKCθ in T cell activation

被引：32

作者：

Sedwick, CE ^{[1
]}

Altman, A ^{[1
]}

机构：

[1] La Jolla Inst Allergy & Immunol, Div Cell Biol, San Diego, CA 92121 USA

来源：

MOLECULAR IMMUNOLOGY | 2004年 / 41卷 / 6-7期

关键词：

PKC theta; TCR; CD28; costimulation; T cell; lipid rafts; immunological synapse;

D O I：

10.1016/j.molimm.2004.01.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Upon stimulation by environmental signals, T lymphocytes develop an intricate set of signal-dependent responses including remodeling of the actin cytoskeleton, the development of cellular polarity, the initiation of second-messenger cascades, entry into cell cycle, differentiation and effector function. The integration of TCR and costimulatory signaling is critical to the successful initiation of the T cell activation program, and the serine/threonine kinase PKCtheta is an important site of signal integration in the process of T cell activation. We provide an overview of T cell signaling, and then go on to assess our understanding of the regulation of PKCtheta activity, its target proteins and its role in T cell activation and the production of T cell survival factors such as IL-2. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：675 / 686

页数：12

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