共 52 条
The integrin αMβ2 anchors hematopoietic progenitors in the bone marrow during enforced mobilization
被引:36
作者:

Hidalgo, A
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA

Peired, AJ
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA

Weiss, LA
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA

Katayama, Y
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA

Frenette, PS
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA
机构:
[1] CUNY Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA
[2] CUNY Mt Sinai Sch Med, Immunobiol Ctr, New York, NY 10029 USA
来源:
关键词:
D O I:
10.1182/blood-2003-10-3702
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
The sulfated polysaccharide fucoidan can rapidly mobilize hematopoietic progenitor cells (HPCs) and long-term repopulating stem cells from the bone marrow (BM) to the circulation. While searching for mechanisms involved in this phenomenon we found that BM myeloid cells bound to fucoidan through the integrin alphaMbeta2(macrophage antigen-1 [Mac-1])and L-selectin resulting in alphaMbeta2-independent release of neutrophil elastase, but inhibition of elastase activity did not impair fucoidan-induced mobilization. Mobilization of HPCs by fucoidan was enhanced in animals deficient in alphaM (alphaM(-/-)) compared with wild-type (alphaM(+/+)) animals and higher plasma levels of the chemokine CXCL12/stromal cell-derived factor-1 (SDF-1) were achieved in alphaM(-/-) mice by fucoidan treatment. However, in chimeric animals harboring alphaM(+/+) and alphaM(-/-) HPCs in the BM, alphaM(-/-) HPCs were preferentially mobilized by fucoidan, suggesting that the enhanced mobilization is cell intrinsic and does not result from altered microenvironment. Suboptimal doses of granulocyte colony-stimulating factor (G-CSF) or cyclophosphamide (CY) also resulted in enhanced HPC mobilization in alphaM(-/-) mice compared with alphaM(+/+) controls, but this difference was overcome when standard doses of G-CSF or CY were administered. Taken together, these data suggest that the integrin alphaMbeta2 participates in the retention of HPCs in the BM. (C) 2004 by The American Society of Hematology.
引用
收藏
页码:993 / 1001
页数:9
相关论文
共 52 条
[31]
THE PURIFICATION AND CHARACTERIZATION OF FETAL LIVER HEMATOPOIETIC STEM-CELLS
[J].
MORRISON, SJ
;
HEMMATI, HD
;
WANDYCZ, AM
;
WEISSMAN, IL
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1995, 92 (22)
:10302-10306

MORRISON, SJ
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT PATHOL,STANFORD,CA 94305

HEMMATI, HD
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT PATHOL,STANFORD,CA 94305

WANDYCZ, AM
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT PATHOL,STANFORD,CA 94305

WEISSMAN, IL
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT PATHOL,STANFORD,CA 94305
[32]
Mechanisms of stem-/progenitor-cell mobilization: The anti-VLA-4 paradigm
[J].
Papayannopoulou, T
.
SEMINARS IN HEMATOLOGY,
2000, 37 (01)
:11-18

Papayannopoulou, T
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Med Hematol, Seattle, WA 98195 USA Univ Washington, Dept Med Hematol, Seattle, WA 98195 USA
[33]
THE VLA4/VCAM-1 ADHESION PATHWAY DEFINES CONTRASTING MECHANISMS OF LODGEMENT OF TRANSPLANTED MURINE HEMATOPOIETIC PROGENITORS BETWEEN BONE-MARROW AND SPLEEN
[J].
PAPAYANNOPOULOU, T
;
CRADDOCK, C
;
NAKAMOTO, B
;
PRIESTLEY, GV
;
WOLF, NS
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1995, 92 (21)
:9647-9651

PAPAYANNOPOULOU, T
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV WASHINGTON, DEPT PATHOL, SEATTLE, WA 98195 USA UNIV WASHINGTON, DEPT PATHOL, SEATTLE, WA 98195 USA

CRADDOCK, C
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV WASHINGTON, DEPT PATHOL, SEATTLE, WA 98195 USA UNIV WASHINGTON, DEPT PATHOL, SEATTLE, WA 98195 USA

NAKAMOTO, B
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV WASHINGTON, DEPT PATHOL, SEATTLE, WA 98195 USA UNIV WASHINGTON, DEPT PATHOL, SEATTLE, WA 98195 USA

PRIESTLEY, GV
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV WASHINGTON, DEPT PATHOL, SEATTLE, WA 98195 USA UNIV WASHINGTON, DEPT PATHOL, SEATTLE, WA 98195 USA

WOLF, NS
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV WASHINGTON, DEPT PATHOL, SEATTLE, WA 98195 USA UNIV WASHINGTON, DEPT PATHOL, SEATTLE, WA 98195 USA
[34]
Heparin inhibits ligand binding to the leukocyte integrin Mac-1 (CD11b/CD18)
[J].
Peter, K
;
Schwarz, M
;
Conradt, C
;
Nordt, T
;
Moser, M
;
Kübler, W
;
Bode, C
.
CIRCULATION,
1999, 100 (14)
:1533-1539

Peter, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Freiburg, Dept Internal Med 3, D-79106 Freiburg, Germany

Schwarz, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Freiburg, Dept Internal Med 3, D-79106 Freiburg, Germany

Conradt, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Freiburg, Dept Internal Med 3, D-79106 Freiburg, Germany

Nordt, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Freiburg, Dept Internal Med 3, D-79106 Freiburg, Germany

Moser, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Freiburg, Dept Internal Med 3, D-79106 Freiburg, Germany

Kübler, W
论文数: 0 引用数: 0
h-index: 0
机构: Univ Freiburg, Dept Internal Med 3, D-79106 Freiburg, Germany

Bode, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Freiburg, Dept Internal Med 3, D-79106 Freiburg, Germany
[35]
G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
[J].
Petit, I
;
Szyper-Kravitz, M
;
Nagler, A
;
Lahav, M
;
Peled, A
;
Habler, L
;
Ponomaryov, T
;
Taichman, RS
;
Arenzana-Seisdedos, F
;
Fujii, N
;
Sandbank, J
;
Zipori, D
;
Lapidot, T
.
NATURE IMMUNOLOGY,
2002, 3 (07)
:687-694

Petit, I
论文数: 0 引用数: 0
h-index: 0
机构: Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

Szyper-Kravitz, M
论文数: 0 引用数: 0
h-index: 0
机构: Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

Nagler, A
论文数: 0 引用数: 0
h-index: 0
机构: Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

Lahav, M
论文数: 0 引用数: 0
h-index: 0
机构: Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

Peled, A
论文数: 0 引用数: 0
h-index: 0
机构: Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

Habler, L
论文数: 0 引用数: 0
h-index: 0
机构: Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

Ponomaryov, T
论文数: 0 引用数: 0
h-index: 0
机构: Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

Taichman, RS
论文数: 0 引用数: 0
h-index: 0
机构: Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

Arenzana-Seisdedos, F
论文数: 0 引用数: 0
h-index: 0
机构: Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

论文数: 引用数:
h-index:
机构:

Sandbank, J
论文数: 0 引用数: 0
h-index: 0
机构: Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

Zipori, D
论文数: 0 引用数: 0
h-index: 0
机构: Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

Lapidot, T
论文数: 0 引用数: 0
h-index: 0
机构:
Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel
[36]
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice:: Mutations in Tlr4 gene
[J].
Poltorak, A
;
He, XL
;
Smirnova, I
;
Liu, MY
;
Van Huffel, C
;
Du, X
;
Birdwell, D
;
Alejos, E
;
Silva, M
;
Galanos, C
;
Freudenberg, M
;
Ricciardi-Castagnoli, P
;
Layton, B
;
Beutler, B
.
SCIENCE,
1998, 282 (5396)
:2085-2088

Poltorak, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75235 USA

He, XL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75235 USA

Smirnova, I
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75235 USA

Liu, MY
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75235 USA

Van Huffel, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75235 USA

Du, X
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75235 USA

Birdwell, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75235 USA

Alejos, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75235 USA

Silva, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75235 USA

Galanos, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75235 USA

Freudenberg, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75235 USA

Ricciardi-Castagnoli, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75235 USA

Layton, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75235 USA

Beutler, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75235 USA
[37]
Neutrophils are indispensable for hematopoietic stem cell mobilization induced by interleukin-8 in mice
[J].
Pruijt, JFM
;
Verzaal, P
;
van Os, R
;
de Kruijf, EJFM
;
van Schie, MLJ
;
Mantovani, A
;
Vecchi, A
;
Lindley, IJD
;
Willemze, R
;
Starckx, S
;
Opdenakker, G
;
Fibbe, WE
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2002, 99 (09)
:6228-6233

Pruijt, JFM
论文数: 0 引用数: 0
h-index: 0
机构: Leiden Univ, Med Ctr, Dept Hematol, Lab Expt Hematol, NL-2300 RC Leiden, Netherlands

Verzaal, P
论文数: 0 引用数: 0
h-index: 0
机构: Leiden Univ, Med Ctr, Dept Hematol, Lab Expt Hematol, NL-2300 RC Leiden, Netherlands

van Os, R
论文数: 0 引用数: 0
h-index: 0
机构: Leiden Univ, Med Ctr, Dept Hematol, Lab Expt Hematol, NL-2300 RC Leiden, Netherlands

de Kruijf, EJFM
论文数: 0 引用数: 0
h-index: 0
机构: Leiden Univ, Med Ctr, Dept Hematol, Lab Expt Hematol, NL-2300 RC Leiden, Netherlands

van Schie, MLJ
论文数: 0 引用数: 0
h-index: 0
机构: Leiden Univ, Med Ctr, Dept Hematol, Lab Expt Hematol, NL-2300 RC Leiden, Netherlands

Mantovani, A
论文数: 0 引用数: 0
h-index: 0
机构: Leiden Univ, Med Ctr, Dept Hematol, Lab Expt Hematol, NL-2300 RC Leiden, Netherlands

Vecchi, A
论文数: 0 引用数: 0
h-index: 0
机构: Leiden Univ, Med Ctr, Dept Hematol, Lab Expt Hematol, NL-2300 RC Leiden, Netherlands

Lindley, IJD
论文数: 0 引用数: 0
h-index: 0
机构: Leiden Univ, Med Ctr, Dept Hematol, Lab Expt Hematol, NL-2300 RC Leiden, Netherlands

Willemze, R
论文数: 0 引用数: 0
h-index: 0
机构: Leiden Univ, Med Ctr, Dept Hematol, Lab Expt Hematol, NL-2300 RC Leiden, Netherlands

Starckx, S
论文数: 0 引用数: 0
h-index: 0
机构: Leiden Univ, Med Ctr, Dept Hematol, Lab Expt Hematol, NL-2300 RC Leiden, Netherlands

Opdenakker, G
论文数: 0 引用数: 0
h-index: 0
机构: Leiden Univ, Med Ctr, Dept Hematol, Lab Expt Hematol, NL-2300 RC Leiden, Netherlands

Fibbe, WE
论文数: 0 引用数: 0
h-index: 0
机构: Leiden Univ, Med Ctr, Dept Hematol, Lab Expt Hematol, NL-2300 RC Leiden, Netherlands
[38]
Phenotypic and functional changes induced at the clonal level in hematopoietic stem cells after 5-fluorouracil treatment
[J].
Randall, TD
;
Weissman, IL
.
BLOOD,
1997, 89 (10)
:3596-3606

Randall, TD
论文数: 0 引用数: 0
h-index: 0

Weissman, IL
论文数: 0 引用数: 0
h-index: 0
[39]
Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment
[J].
Robinson, SD
;
Frenette, PS
;
Rayburn, H
;
Cummiskey, M
;
Ullman-Culleré, M
;
Wagner, DD
;
Hynes, RO
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1999, 96 (20)
:11452-11457

Robinson, SD
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02139 USA

Frenette, PS
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02139 USA

Rayburn, H
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02139 USA

Cummiskey, M
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02139 USA

Ullman-Culleré, M
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02139 USA

Wagner, DD
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02139 USA

Hynes, RO
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02139 USA
[40]
Role of the lectin domain of Mac-1/CR3 (CD11b/CD18) in regulating intercellular adhesion
[J].
Ross, GD
.
IMMUNOLOGIC RESEARCH,
2002, 25 (03)
:219-227

Ross, GD
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Louisville, Dept Pathol, James Graham Brown Canc Ctr, Div Expt Immunol & Immunopathol, Louisville, KY 40292 USA Univ Louisville, Dept Pathol, James Graham Brown Canc Ctr, Div Expt Immunol & Immunopathol, Louisville, KY 40292 USA