学术探索
学术期刊
新闻热点
数据分析
智能评审

The complexity of chromatin remodeling and its links to cancer

被引：91
作者：
Neely, KE
Workman, JL [1 ]
机构：
[1] Penn State Univ, Howard Hughes Med Inst, Althouse Lab 306, University Pk, PA 16802 USA
[2] Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2002年 / 1603卷 / 01期
关键词：
ATP-dependent chromatin remodeling; SWI/SNF; ISWI; CHD; cancer;
D O I：
10.1016/S0304-419X(02)00067-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The relief of chromatin-mediated repression by ATP-dependent chromatin-remodeling complexes is an important step in the proper transcriptional regulation of many genes. This review gives an organized summary of this large group of complexes that exist in yeast, flies, and humans. Their subunit composition and brief overview of their functional properties will be discussed. Also, current links between human chromatin-remodeling complexes and cell growth and cancer will be presented. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：19 / 29
页数：11
相关论文
共 153 条
  • [1] Aasland R, 1996, TRENDS BIOCHEM SCI, V21, P87, DOI 10.1016/0968-0004(96)30009-1
  • [2] Chromodomains are protein-RNA interaction modules
    Akhtar, A
    Zink, D
    Becker, PB
    [J]. NATURE, 2000, 407 (6802) : 405 - 409
  • [3] A Rsc3/Rsc30 zinc cluster dimer reveals novel roles for the chromatin remodeler RSC in gene expression and cell cycle control
    Angus-Hill, ML
    Schlichter, A
    Roberts, D
    Erdjument-Bromage, H
    Tempst, P
    Cairns, BR
    [J]. MOLECULAR CELL, 2001, 7 (04) : 741 - 751
  • [4] A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro
    Armstrong, JA
    Bieker, JJ
    Emerson, BM
    [J]. CELL, 1998, 95 (01) : 93 - 104
  • [5] Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
    Bannister, AJ
    Zegerman, P
    Partridge, JF
    Miska, EA
    Thomas, JO
    Allshire, RC
    Kouzarides, T
    [J]. NATURE, 2001, 410 (6824) : 120 - 124
  • [6] Bazett-Jones DP, 1999, MOL CELL BIOL, V19, P1470
  • [7] An embarrassment of niches: the many covalent modifications of histones in transcriptional regulation
    Berger, SL
    [J]. ONCOGENE, 2001, 20 (24) : 3007 - 3013
  • [8] Biegel JA, 2000, CLIN CANCER RES, V6, P2759
  • [9] Biegel JA, 2000, GENE CHROMOSOME CANC, V28, P31, DOI 10.1002/(SICI)1098-2264(200005)28:1<31::AID-GCC4>3.0.CO
  • [10] 2-Y
12345678910