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The complexity of chromatin remodeling and its links to cancer

被引：91
作者：
Neely, KE
Workman, JL [1 ]
机构：
[1] Penn State Univ, Howard Hughes Med Inst, Althouse Lab 306, University Pk, PA 16802 USA
[2] Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2002年 / 1603卷 / 01期
关键词：
ATP-dependent chromatin remodeling; SWI/SNF; ISWI; CHD; cancer;
D O I：
10.1016/S0304-419X(02)00067-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The relief of chromatin-mediated repression by ATP-dependent chromatin-remodeling complexes is an important step in the proper transcriptional regulation of many genes. This review gives an organized summary of this large group of complexes that exist in yeast, flies, and humans. Their subunit composition and brief overview of their functional properties will be discussed. Also, current links between human chromatin-remodeling complexes and cell growth and cancer will be presented. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
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页码：19 / 29
页数：11
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