Efficient synthesis of (-)-(R)-muscone by enantioselective protonation

被引：29

作者：

Fehr, C ^{[1
]}

Galindo, J ^{[1
]}

Farris, I ^{[1
]}

Cuenca, A ^{[1
]}

机构：

[1] Firmenich SA Corp, Div Res & Dev, CH-1211 Geneva 8, Switzerland

来源：

HELVETICA CHIMICA ACTA | 2004年 / 87卷 / 07期

关键词：

D O I：

10.1002/hlca.200490157

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new synthesis of (-)-(R)-muscone ((R)-1) by means of enantioselective protonation of a bicyclic ketone enolate as the key step (see 6 --> (S)-4 in Scheme 2) is presented. The C-15 macrocyclic system is obtained by ozonolysis (Scheme 7).

引用

页码：1737 / 1747

页数：11

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