Regulation of pyruvate dehydrogenase (PDH) activity in human skeletal muscle during exercise

被引：66

作者：

Spriet, LL

Heigenhauser, GJF

机构：

[1] Univ Guelph, Dept Human Biol & Nutr Sci, Guelph, ON N1G 2W1, Canada

[2] McMaster Univ, Dept Med, Hamilton, ON, Canada

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2002年 / 30卷 / 02期

关键词：

carbohydrate oxidation; mitochondrion; PDH kinase; PDH phosphatase;

D O I：

10.1097/00003677-200204000-00009

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

SPRIET, L.L., and G.J.F. HEIGENHAUSER. Regulation of pyruvate dehydrogenase (PDH) activity in human skeletal muscle during exercise. Exerc. Sport Sci. Rev., Vol. 30, No. 2, pp. 91-95, 2002. Pyruvate dehydrogenase is a mitochondrial multienzyme complex that catalyzes the conversion of pyruvate to acetyl-coenzyme A and regulates the entry of carbohydrate into the tricarboxylic acid cycle for oxidation. During exercise, pyruvate dehydrogenase activation in human skeletal muscle is proportional to the relative aerobic power output (percent VO(2)max) and is regulated by increases in Ca, free ADP, and pyruvate concentrations.

引用

页码：91 / 95

页数：5

共 15 条

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