Aurora A and B kinases as targets for cancer: will they be selective for tumors?

被引：67

作者：

Matthews, Nick

Visintin, Cristina

Hartzoulakis, Basil

Jarvis, Ashley

Selwood, David L.

机构：

[1] Inploid Ltd, Oxford BioBusiness Ctr, Oxford OX4 4SS, England

[2] UCL, Wolfson Inst Biomed Res, Biol & Med Chem Grp, London WC1E 6BT, England

[3] NCE Discovery Ltd, Cambridge CB4 OPZ, England

来源：

EXPERT REVIEW OF ANTICANCER THERAPY | 2006年 / 6卷 / 01期

关键词：

Aurora A kinase; Aurora B kinase; clinical status; inhibitors; resistance; mutations;

D O I：

10.1586/14737140.6.1.109

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aurora A and B kinases are closely related kinases involved in regulating separate points in the cell cycle. This review highlights the rationale for Aurora kinases as cancer targets and examines the currently known Aurora kinase inhibitors in the patent and scientific literature. The known crystal structures of the Aurora kinases are described with relevance to bound ligand interactions and the prospect of the generation of drug-resistant mutant forms. The potential for selectivity versus primary cells will also be discussed. The status of the inhibitors in clinical development is described.

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页码：109 / 120

页数：12

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