Circulating and Disseminated Tumor Cells in the Clinical Management of Breast Cancer Patients: Unanswered Questions

被引：22

作者：

Amadori, A. ^{[1
]}

Rossi, E. ^{[1
]}

Zamarchi, R. ^{[1
]}

Carli, P. ^{[1
]}

Pastorelli, D. ^{[1
]}

Jirillo, A. ^{[1
]}

机构：

[1] Ist Oncol Veneto IRCCS, IT-35128 Padua, Italy

来源：

ONCOLOGY | 2009年 / 76卷 / 06期

关键词：

Breast cancer; Cell growth; Circulating tumor cells; Disseminated tumor cells; Prognostic factor; BONE-MARROW MICROMETASTASES; POLYMERASE-CHAIN-REACTION; MINIMAL RESIDUAL DISEASE; RNA-POSITIVE CELLS; PERIPHERAL-BLOOD; ADJUVANT CHEMOTHERAPY; EPITHELIAL-CELLS; CARCINOMA-CELLS; EARLY RELAPSE; STEM-CELL;

D O I：

10.1159/000215581

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer is the most common cancer in women. Although survival rates have improved with the use of new therapeutic agents, many issues remain unresolved and new predictive and prognostic factors are needed in clinical practice. Several studies have suggested a prognostic and predictive role for circulating and disseminated tumor cells in metastatic disease and adjuvant treatment. Because of recent technological advances, oncologists have gained a new perspective on this disease. Circulating tumor cells could be both a new tumor marker as well as a tool to gain novel insight into the natural history of this neoplastic disease. Copyright (C) 2009 S. Karger AG, Basel

引用

收藏

页码：375 / 386

页数：12

相关论文

共 82 条

[71] Quantification and phenotypic characterization of circulating tumor cells for monitoring response to a preventive HER2/neu vaccine-based immunotherapy for breast cancer:: A pilot study [J].

Stojadinovic, Alexander ;

Mittendorf, Elizabeth A. ;

Holmes, Jarrod P. ;

Amin, Asna ;

Hueman, Matthew T. ;

Ponniah, Sathibalan ;

Peoples, George E. .

ANNALS OF SURGICAL ONCOLOGY, 2007, 14 (12) :3359-3368

[72] Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer [J].

Weigelt, B ;

Hu, ZY ;

He, XP ;

Livasy, C ;

Carey, LA ;

Ewend, MG ;

Glas, AM ;

Perou, CM ;

van't Veer, LJ .

CANCER RESEARCH, 2005, 65 (20) :9155-9158

[73] Isolated tumor cells in bone marrow three years after diagnosis in disease-free breast cancer patients predict unfavorable clinical outcome [J].

Wiedswang, G ;

Borgen, E ;

Kåresen, R ;

Qvist, H ;

Janbu, J ;

Kvalheim, G ;

Nesland, JM ;

Naume, B .

CLINICAL CANCER RESEARCH, 2004, 10 (16) :5342-5348

[74] Comparison of the clinical significance of occult tumor cells in blood and bone marrow in breast cancer [J].

Wiedswang, G ;

Borgen, E ;

Schirmer, C ;

Kåresen, R ;

Kvalheim, G ;

Nesland, JM ;

Naume, B .

INTERNATIONAL JOURNAL OF CANCER, 2006, 118 (08) :2013-2019

[75]

Woelfle U, 2003, CANCER RES, V63, P5679

[76] HER2-positive circulating tumor cells indicate poor clinical outcome in stage I to III breast cancer patients [J].

Wülfing, P ;

Borchard, J ;

Buerger, H ;

Heidl, S ;

Zänker, KS ;

Kiesel, L ;

Brandt, B .

CLINICAL CANCER RESEARCH, 2006, 12 (06) :1715-1720

[77] Peripheral blood circulating cytokeratin-19 mRNA-positive cells after the completion of adjuvant chemotherapy in patients with operable breast cancer [J].

Xenidis, N ;

Vlachonikolis, I ;

Mavroudis, D ;

Perraki, M ;

Stathopoulou, A ;

Malamos, N ;

Kouroussis, C ;

Kakolyris, S ;

Apostolaki, S ;

Vardakis, N ;

Lianidou, E ;

Georgoulias, V .

ANNALS OF ONCOLOGY, 2003, 14 (06) :849-855

[78] Predictive and prognostic value of peripheral blood cytokeratin-19 mRNA-positive cells detected by real-time polymerase chain reaction in node-negative breast cancer patients [J].

Xenidis, Nikos ;

Perraki, Maria ;

Kafousi, Maria ;

Apostolaki, Stella ;

Bolonaki, Irene ;

Stathopoulou, Aliki ;

Kalbakis, Kostas ;

Androulakis, Nikos ;

Kouroussis, Charalambos ;

Pallis, Thanos ;

Christophylakis, Charalambos ;

Argyraki, Katerina ;

Lianidou, Evi S. ;

Stathopoulos, Stathis ;

Georgoulias, Vassilis ;

Mavroudis, Dimitris .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (23) :3756-3762

[79] Low-level expression of HER2 and CK19 in normal peripheral blood mononuclear cells: relevance for detection of circulating tumor cells [J].

You, Fanglei ;

Roberts, Lisa A. ;

Kang, S. Peter ;

Nunes, Raquel A. ;

Dias, Cinara ;

Iglehart, J. Dirk ;

Solomon, Natalie A. ;

Friedman, Paula N. ;

Harris, Lyndsay N. .

JOURNAL OF HEMATOLOGY & ONCOLOGY, 2008, 1 (1)

[80]

ZEIDMAN I, 1950, CANCER RES, V10, P357

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