Tumor necrosis factor:: a master-regulator of leukocyte movement

被引：195

作者：

Sedgwick, JD

Riminton, DS

Cyster, JG

Körner, H

机构：

[1] DNAX Res Inst Molec & Cellular Biol Inc, Palo Alto, CA 94304 USA

[2] B93 Royal Prince Alfred Hosp, Centenary Inst Canc Med & Cell Biol, Sydney, NSW 2050, Australia

[3] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

[4] Interdisziplinares Zentrum Klin Forsch, D-91054 Erlangen, Germany

[5] Inst Klin Mikrobiol Immunol & Hyg, D-91054 Erlangen, Germany

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 03期

关键词：

D O I：

10.1016/S0167-5699(99)01573-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tumor necrosis factor (TNF)-mediated activities are potentially numerous, although in TNF-deficient ((-/-)) mice, altered spatial orientation of leukocytes within tissues is the predominant phenotype. Here, we propose that TNF plays a fundamental role in the control of leukocyte movement by virtue of a pivotal role in regulation of chemokine expression.

引用

收藏

页码：110 / 113

页数：6

相关论文

共 32 条

[1] REGULATION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 EXPRESSION IN ADULT HUMAN NONNEOPLASTIC ASTROCYTES IS SENSITIVE TO TUMOR-NECROSIS-FACTOR (TNF) OR ANTIBODY TO THE 55-KDA TNF RECEPTOR [J].

BARNA, BP ;

PETTAY, J ;

BARNETT, GH ;

ZHOU, P ;

IWASAKI, K ;

ESTES, ML .

JOURNAL OF NEUROIMMUNOLOGY, 1994, 50 (01) :101-107

[2] The tumor necrosis factor ligand and receptor families [J].

Bazzoni, F ;

Beutler, B .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (26) :1717-1725

[3]

Bean AGD, 1999, J IMMUNOL, V162, P3504

[4] TNF-alpha and IFN-gamma-mediated signal transduction pathways: Effects on glial cell gene expression and function [J].

Benveniste, EN ;

Benos, DJ .

FASEB JOURNAL, 1995, 9 (15) :1577-1584

[5] Generation of splenic follicular structure and B cell movement in tumor necrosis factor-deficient mice [J].

Cook, MC ;

Körner, H ;

Riminton, DS ;

Lemckert, FA ;

Hasbold, J ;

Amesbury, M ;

Hodgkin, PD ;

Cyster, JG ;

Sedgwick, JD ;

Basten, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (08) :1503-1510

[6] Regulation of autoimmunity by proinflammatory cytokines [J].

Cope, AP .

CURRENT OPINION IN IMMUNOLOGY, 1998, 10 (06) :669-676

[7]

Czermak BJ, 1999, J IMMUNOL, V162, P2321

[8] Mature follicular dendritic cell networks depend on expression of lymphotoxin β receptor by radioresistant stromal cells and of lymphotoxin β and tumor necrosis factor by B cells [J].

Endres, R ;

Alimzhanov, MB ;

Plitz, T ;

Fütterer, A ;

Kosco-Vilbois, MH ;

Nedospasov, SA ;

Rajewsky, K ;

Pfeffer, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (01) :159-167

[9] Role of cytokines in rheumatoid arthritis [J].

Feldmann, M ;

Brennan, FM ;

Maini, RN .

ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :397-440

[10] Development and maturation of secondary lymphoid tissues [J].

Fu, YX ;

Chaplin, DD .

ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 :399-433

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