Salvage chemotherapy for metastatic and recurrent ependymoma of childhood

被引：44

作者：

Bouffet, Eric ^{[1
]}

Capra, Michael ^{[2
]}

Bartels, Ute ^{[1
]}

机构：

[1] Hosp Sick Children, Paediat Neurooncol Program, Toronto, ON M5G 1X8, Canada

[2] Our Ladys Childrens Hosp, Dept Paediat Oncol Haematol, Dublin 12, Ireland

来源：

CHILDS NERVOUS SYSTEM | 2009年 / 25卷 / 10期

关键词：

Recurrent ependymoma; Metastatic ependymoma; Chemotherapy; PEDIATRIC-ONCOLOGY-GROUP; NERVOUS-SYSTEM TUMORS; PHASE-II EVALUATION; BRAIN-TUMORS; INTRACRANIAL EPENDYMOMA; ORAL ETOPOSIDE; SOLID TUMORS; AZIRIDINYLBENZOQUINONE AZQ; YOUNG-CHILDREN; CLINICAL-TRIAL;

D O I：

10.1007/s00381-009-0883-x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Chemotherapy has limited role in the up-front management of ependymoma. At the time of recurrence, the role of chemotherapy is also ill defined and the choice of chemotherapeutic agents is often arbitrary, based on anecdotal data and personal experience. The purpose of this review is to describe and critically analyze the published literature on chemotherapy in patients with recurrent and metastatic ependymoma. The disappointing response rate with single agents (12.9%) and combinations (17.4%) emphasizes the need to re-evaluate the current chemotherapeutic approach of intracranial ependymoma, and biological studies are needed to identify targets that may be considered for clinical trials.

引用

页码：1293 / 1301

页数：9

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