Cytotoxic flavonoids and α-pyrones from Cryptocarya obovata

被引：93

作者：

Dumontet, V

Van Hung, N

Adeline, MT

Riche, C

Chiaroni, A

Sévenet, T

Guéritte, F

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

[2] NCST, Inst Chem, Hanoi, Vietnam

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 05期

关键词：

D O I：

10.1021/np030510h

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

One cc-pyrone, obolactone (1), two chalcones, kurzichalcolactone B (2) and obochalcolactone (3), and two flavanones, oboflavanones A (4) and B (5), have been isolated from the fruits and the trunk bark of Cryptocarya obovata. The structures of the new compounds were elucidated by spectroscopic interpretations. The absolute configuration of obolactone (1) was established by circular dichroism. Obolactone (1) and obochalcolactone (3) display significant activity in in vitro cytotoxic assays against the KB cell line. Biosynthetic pathways for oboflavanones and obochalcolactone are suggested.

引用

页码：858 / 862

页数：5

共 17 条

[1] PROANTHOCYANIDINS FROM STEM BARK OF PAVETTA-OWARIENSIS .2. DIMERIC AND TRIMERIC PROANTHOCYANIDINS POSSESSING A DOUBLY LINKED STRUCTURE FROM PAVETTA-OWARIENSIS [J].