Quality of life in patients with axonal polyneuropathy

被引:40
作者
Teunissen, LL [1 ]
Eurelings, M [1 ]
Notermans, NC [1 ]
Hop, JW [1 ]
van Gijn, J [1 ]
机构
[1] Univ Utrecht, Med Ctr, Dept Neurol, NL-3508 GA Utrecht, Netherlands
关键词
quality of life; chronic neuropathy; RAND-36; axonal neuropathy;
D O I
10.1007/s004150050562
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Quality of life (QOL) measurement reflects the impact of a disease on the daily life of a patient, and this can be used as an outcome measure in clinical trials. QOL measurements are rarely used in patients with neuromuscular disease. The aim of this study was to determine whether QOL is reduced in chronic polyneuropathy, whether there is a relationship between QOL and objective measures of disease severity, and whether measuring QOL is a useful addition to the assessment of severity of polyneuropathy. We measured QOL in 90 patients with chronic axonal polyneuropathy (33 with hereditary motor and sensory neuropathy type II and 57 with chronic idiopathic axonal polyneuropathy) using the RAND 36-item Health Survey questionnaire (RAND-36). We compared the results with the QOL of a reference population, with summed motor and sensory scores, and with the Rankin scale for handicap. Patients had worse scores than the reference population on seven of eight areas of the RAND-36. Patients with both low motor and low sensory scores rated lower in physical and emotional areas than less impaired patients. A low Rankin score was related only to physical domains. We conclude that in patients with chronic axonal polyneuropathy the severity of disease can be assessed with a general QOL instrument, and that this provides additional information, particularly on areas related to emotional and social functioning.
引用
收藏
页码:195 / 199
页数:5
相关论文
共 18 条
  • [11] Epidemiology of peripheral neuropathy
    Martyn, C
    Hughes, RAC
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1997, 62 (04) : 310 - 318
  • [12] CHRONIC IDIOPATHIC POLYNEUROPATHY PRESENTING IN MIDDLE OR OLD-AGE - A CLINICAL AND ELECTROPHYSIOLOGICAL STUDY OF 75 PATIENTS
    NOTERMANS, NC
    WOKKE, JHJ
    FRANSSEN, H
    VANDERGRAAF, Y
    VERMEULEN, M
    VANDENBERG, LH
    BAR, PR
    JENNEKENS, FGI
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1993, 56 (10) : 1066 - 1071
  • [13] QUALITY-OF-LIFE IN MULTIPLE-SCLEROSIS - COMPARISON WITH INFLAMMATORY BOWEL-DISEASE AND RHEUMATOID-ARTHRITIS
    RUDICK, RA
    MILLER, D
    CLOUGH, JD
    GRAGG, LA
    FARMER, RG
    [J]. ARCHIVES OF NEUROLOGY, 1992, 49 (12) : 1237 - 1242
  • [14] FUNCTIONAL STATUS AND WELL-BEING OF PATIENTS WITH CHRONIC CONDITIONS - RESULTS FROM THE MEDICAL OUTCOMES STUDY
    STEWART, AL
    GREENFIELD, S
    HAYS, RD
    WELLS, K
    ROGERS, WH
    BERRY, SD
    MCGLYNN, EA
    WARE, JE
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1989, 262 (07): : 907 - 913
  • [15] Differences between hereditary motor and sensory neuropathy type 2 and chronic idiopathic axonal neuropathy - A clinical and electrophysiological study
    Teunissen, LL
    Notermans, NC
    Franssen, H
    vanderGraaf, Y
    Oey, PL
    Linssen, WHJP
    vanEngelen, BGM
    Ippel, PF
    vanDijk, GW
    GabreelsFesten, AAWM
    Wokke, JHJ
    [J]. BRAIN, 1997, 120 : 955 - 962
  • [16] VANDERZEE KI, 1993, TIJDSCHRIFT SOCIALE, V71, P183
  • [17] VANDERZEE KI, 1985, METEN ALGEMENE GEZON
  • [18] THE MOS 36-ITEM SHORT-FORM HEALTH SURVEY (SF-36) .1. CONCEPTUAL-FRAMEWORK AND ITEM SELECTION
    WARE, JE
    SHERBOURNE, CD
    [J]. MEDICAL CARE, 1992, 30 (06) : 473 - 483