Impact of donor-recipient MHC matching on experimental islet allotransplant survival in naive and presensitized Lewis rats

被引：7

作者：

Bittscheidt, H ^{[1
]}

Bektas, H ^{[1
]}

Winkler, M ^{[1
]}

Klempnauer, J ^{[1
]}

机构：

[1] Hannover Med Sch, Dept Visceral & Transplantat Surg, D-30625 Hannover, Germany

来源：

TRANSPLANTATION | 2004年 / 78卷 / 01期

关键词：

islet transplantation; presensitization; HLA; MHC; matching; rats;

D O I：

10.1097/01.TP.0000133539.74599.0B

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

in human islet transplantation (ITX), the impact of donor-recipient major histocompatibility complex (MHC) matching on transplant survival is currently unknown. Utilizing defined MHC mismatches, we have investigated the outcome of ITX in naive and presensitized congenic Lewis rats. ITX into streptozotocin diabetic Lewis rats was performed under the kidney capsule. Presensitization by skin transplantation was performed on days 1, 28, and 56, followed by ITX on day 84. Survival was greatest in isolated MHC class I mismatches, followed by isolated MHC class II mismatches. The shortest transplant survival was observed following full MHC mismatched ITX (P<0.05 vs. isolated MHC class I or II). Following recipient presensitization, islets in general showed reduced survival compared to naive recipients. In this congenic rat model, islet transplant survival was significantly influenced by the degree of donor-recipient MHC matching, as well as by recipient presensitization. These data suggest that MHC matching might be useful in human islet transplantation.

引用

页码：162 / 164

页数：3

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