The ongoing heavy burden of cardiovascular disease associated with diabetes mellitus highlights the failure of current treatment strategies to address effectively the cardiovascular risk profile in such patients. Insulin resistance is not only an underlying feature in most cases of type 2 diabetes, but is also associated, through the Insulin Resistance Syndrome, with cardiovascular risk factors that promote atherothrombosis through diverse mechanisms. Growing evidence suggests that treatment with anti-diabetic agents that improve insulin sensitivity, such as the thiazolidinediones, improve multiple components of the Insulin Resistance Syndrome, have beneficial effects on various atherothrombotic mechanisms, and reduce atherosclerosis in animal models and perhaps humans as well. Given data implicating chronic inflammation as a central feature of atherosclerosis, the anti-inflammatory activity of the thiazolidinediones may contribute to their potential anti-atherosclerotic effects. An improved understanding of the mechanisms linking diabetes, atherosclerosis, and cardiovascular disease is needed in order to understand how these and other current and emerging therapies might reduce diabetes-associated cardiovascular disease. (C) 2002 Elsevier Science Inc. All rights reserved.
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Fukushima Med Univ, Sch Med, Dept Internal Med 3, Fukushima 9601295, JapanFukushima Med Univ, Sch Med, Dept Internal Med 3, Fukushima 9601295, Japan
Kato, K
Satoh, H
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Satoh, H
Endo, Y
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机构:Fukushima Med Univ, Sch Med, Dept Internal Med 3, Fukushima 9601295, Japan
Endo, Y
Yamada, D
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Yamada, D
Midorikawa, S
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Midorikawa, S
Sato, W
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Sato, W
Mizuno, K
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Mizuno, K
Fujita, T
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Fujita, T
Tsukamoto, K
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Tsukamoto, K
Watanabe, T
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机构:Fukushima Med Univ, Sch Med, Dept Internal Med 3, Fukushima 9601295, Japan
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Fukushima Med Univ, Sch Med, Dept Internal Med 3, Fukushima 9601295, JapanFukushima Med Univ, Sch Med, Dept Internal Med 3, Fukushima 9601295, Japan
Kato, K
Satoh, H
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机构:Fukushima Med Univ, Sch Med, Dept Internal Med 3, Fukushima 9601295, Japan
Satoh, H
Endo, Y
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机构:Fukushima Med Univ, Sch Med, Dept Internal Med 3, Fukushima 9601295, Japan
Endo, Y
Yamada, D
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机构:Fukushima Med Univ, Sch Med, Dept Internal Med 3, Fukushima 9601295, Japan
Yamada, D
Midorikawa, S
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机构:Fukushima Med Univ, Sch Med, Dept Internal Med 3, Fukushima 9601295, Japan
Midorikawa, S
Sato, W
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机构:Fukushima Med Univ, Sch Med, Dept Internal Med 3, Fukushima 9601295, Japan
Sato, W
Mizuno, K
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机构:Fukushima Med Univ, Sch Med, Dept Internal Med 3, Fukushima 9601295, Japan
Mizuno, K
Fujita, T
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机构:Fukushima Med Univ, Sch Med, Dept Internal Med 3, Fukushima 9601295, Japan
Fujita, T
Tsukamoto, K
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机构:Fukushima Med Univ, Sch Med, Dept Internal Med 3, Fukushima 9601295, Japan
Tsukamoto, K
Watanabe, T
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机构:Fukushima Med Univ, Sch Med, Dept Internal Med 3, Fukushima 9601295, Japan