Epidemiology of Human Influenza A and B Viruses in Myanmar from 2005 to 2007

被引：49

作者：

Dapat, Clyde ^{[1
]}

Saito, Reiko ^{[1
]}

Kyaw, Yadanar ^{[3
]}

Naito, Makoto ^{[2
]}

Hasegawa, Go ^{[2
]}

Suzuki, Yasushi ^{[1
]}

Dapat, Isolde C. ^{[1
]}

Zaraket, Hassan ^{[1
]}

Cho, Tin Maung ^{[4
]}

Li, Danjuan ^{[1
]}

Oguma, Taeko ^{[1
]}

Baranovich, Tatiana ^{[1
]}

Suzuki, Hiroshi ^{[1
]}

机构：

[1] Niigata Univ, Grad Sch Med & Dent Sci, Dept Publ Hlth, Niigata 9518510, Japan

[2] Niigata Univ, Grad Sch Med & Dent Sci, Div Cellular & Mol Pathol, Niigata 9518510, Japan

[3] Sanpya Hosp, Chest Med Unit, Yangon, Myanmar

[4] Yangon Gen Hosp, Dept Resp Med, Yangon, Myanmar

来源：

INTERVIROLOGY | 2009年 / 52卷 / 06期

关键词：

Amantadine-resistant influenza A viruses; Human influenza A and B viruses; epidemiology; Influenza A/H1N1 viruses; Influenza A/H3N2 Isolates; Influenza B viruses; Influenza surveillance; Myanmar; Sentinel influenza surveillance sites; Victoria-lineage isolates; Yamagata-lineage isolates; ADAMANTANE RESISTANCE; SEQUENCE-ANALYSIS; GENETIC-ANALYSIS; H3N2; VIRUS; STRAINS; SEASON; INFECTIONS; REASSORTMENT; AUSTRALIA; VARIANTS;

D O I：

10.1159/000237738

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Objectives: To perform genetic analysis of influenza A and B viruses in Myanmar from 2005 to 2007 and to determine the prevalence of amantadine-resistant influenza A viruses. Methods: Phylogenies of the HA and NA genes were analyzed and mutations in M2 that confer resistance to amantadine were screened. Results: Influenza in Myanmar exhibited seasonality, which coincided during the rainy season from June to August. Out of 2,618 samples, 76 influenza A and 132 influenza B viruses were isolated. Phylogenetic analysis showed that in 2005, 11 A/H1N1 isolates formed one cluster with A/Solomon Islands/3/2006 and were amantadine-sensitive strains. One A/H3N2 isolate was amantadine-resistant harboring S31N mutation in M2 and possessing S193F and D225N substitutions in HA (clade N), similar to A/Wisconsin/67/2005. No viruses were isolated in 2006 due to sample storage failure. In 2007, all 64 A/H3N2 isolates were amantadine-resistant and similar to A/Brisbane/10/2007. For influenza B, 3 Yamagata-lineage and 17 Victoria-lineage isolates were detected in 2005 and 112 Victoria-lineage viruses were isolated in 2007. All Victoria-lineage isolates were reassortants possessing NA derived from the Yamagata lineage. Conclusion: Continuous surveillance in tropical countries is important for elucidating the seasonality of influenza and determining the molecular characteristics of circulating strains. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：310 / 320

页数：11