Hypocrellin D, a cytotoxic fungal pigment from fruiting bodies of the ascomycete Shiraia bambusicola

被引：47

作者：

Fang, Li-Zhen

Qing, Chen

Shao, Hong-Jun

Yang, Yi-Dong

Dong, Ze-Jun

Wang, Fei

Zhao, Wei

Yang, Wan-Qiu

Liu, Ji-Kai ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resource W China, Kunming 650204, Peoples R China

[2] Kunming Med Coll, Kunming 650031, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Beijing 1000439, Peoples R China

来源：

JOURNAL OF ANTIBIOTICS | 2006年 / 59卷 / 06期

基金：

中国国家自然科学基金;

关键词：

hypocrellin D; perylenequinone; Shiraia bambusicola; pigment; ascomycete; cytotoxicity;

D O I：

10.1038/ja.2006.49

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

A fungal pigment, hypocrellin D (1), together with three known perylenequinone derivatives hypocrellin A (2), B (3) and C (4), was isolated from the fruiting bodies of Shiraia bambusicola. Its structure was elucidated on the basis of spectral data including 2D NMR experiments. Hypocrellin D (1) significantly inhibited the growth of tumor cell lines Bel-7721, A-549 and Anip-973 with IC50 values of 1.8, 8.8, 38.4, mu g/ml, respectively.

引用

页码：351 / 354

页数：4

共 17 条

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ALLEY MC, 1988, CANCER RES, V48, P589

[2]

SECONDARY MOLD METABOLITES .13. FUNGAL PERYLENEQUINONES - PHLEICHROME, ISOPHLEICHROME, AND THEIR ENDOPEROXIDES [J].