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Bovine spongiform encephalopathy and Creutzfeldt-Jakob disease: facts and uncertainties underlying the causal link between animal and human diseases

被引：9
作者：
Beghi, E
Gandolfo, C
Ferrarese, C
Rizzuto, N
Poli, G
Tonini, MC
Vita, G
Leone, M
Logroscino, G
Granieri, E
Salemi, G
Savettieri, G
Frattola, L
Ru, G
Mancardi, GL
Messina, C
机构：
[1] Mario Negri Inst Pharmacol Res, I-20157 Milan, Italy
[2] Univ Milano Bicocca, Neurol Clin, Monza, Italy
[3] Univ Genoa, Neurol Clin, I-16126 Genoa, Italy
[4] Univ Verona, Policlin Borgo Roma, Neurol Clin, I-37134 Verona, Italy
[5] Univ Milan, Fac Vet Med, I-20122 Milan, Italy
[6] G Salvini Hosp, Div Neurol, Garbagnate Milanese, MI, Italy
[7] Politech Univ G Martini, Neurol Clin 2, Messina, Italy
[8] Osped Maggiore La Carita, Neurol Clin, Novara, Italy
[9] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[10] Univ Ferrara, Neurol Clin, I-44100 Ferrara, Italy
[11] Univ Palermo, Inst Neuropsychiat, I-90133 Palermo, Italy
[12] Univ Palermo, Dept Neurosci, I-90133 Palermo, Italy
[13] IRCSS Don Gnocchi Fdn, Milan, Italy
[14] Ist Zooprofilattico, Turin, Italy
来源：
NEUROLOGICAL SCIENCES | 2004年 / 25卷 / 03期
关键词：
bovine spongiform encephalopathy; Creutzfeldt-Jakob disease; epidemiology;
D O I：
10.1007/s10072-004-0249-9
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Following an outbreak of bovine spongiform encephalopathy (BSE) in dairy cows in the United Kingdom (UK), 153 definite and probable human cases of new variant Creutzfeldt-Jakob disease (nvCJD) have been reported, almost exclusively in the UK. Although exposure to the BSE agent is the most plausible interpretation for the occurrence of nvCJD, the causal link between the BSE prion and nvCJD is still debated. This review discusses the pros and cons of nvCJD as a separate nosographic entity, the scientific basis for a correlation between BSE and nvCJD, the validity of the current diagnostic criteria for CJD and nvCJD, the contribution of epidemiology to the detection of a causal relation between BSE and nvCJD, and the present and future directions of the epidemiological research on BSE, CJD and nvCJD.
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收藏
页码：122 / 129
页数：8
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