Deaths from variant Creutzfeldt-Jakob disease in the UK

被引:51
作者
Andrews, NJ
Farrington, CP
Ward, HJT
Cousens, SN
Smith, PG
Molesworth, AM
Knight, RSG
Ironside, JW
Will, RG [1 ]
机构
[1] Western Gen Hosp, Natl CJD Surveillance Unit, Edinburgh EH4 2XU, Midlothian, Scotland
[2] Publ Hlth Lab Serv, Ctr Communicable Dis Surveillance, London NW9 5EQ, England
[3] Open Univ, Dept Stat, Milton Keynes MK7 6AA, Bucks, England
[4] London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1, England
关键词
D O I
10.1016/S0140-6736(03)12632-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In 2002, 17 people died. from variant CJD (vCJD) in the UK, compared with 20 in 2001 and 28 in 2000. We analysed data for deaths from vCJD since 1995 and estimated the underlying trend in mortality. The trend had a quadratic component (p=0.005), suggesting that the Increase was not exponential, and that the previously increasing trend is slowing down. The death rate peaked in 2000. These findings are encouraging, but mortality might increase again in the future.
引用
收藏
页码:751 / 752
页数:2
相关论文
共 5 条
[1]   Incidence of variant Creutzfeldt-Jakob disease in the UK [J].
Andrews, NJ ;
Farrington, CP ;
Cousens, SN ;
Smith, PG ;
Ward, H ;
Knight, RSG ;
Ironside, JW ;
Will, RG .
LANCET, 2000, 356 (9228) :481-482
[2]   Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent [J].
Bruce, ME ;
Will, RG ;
Ironside, JW ;
McConnell, I ;
Drummond, D ;
Suttie, A ;
McCardle, L ;
Chree, A ;
Hope, J ;
Birkett, C ;
Cousens, S ;
Fraser, H ;
Bostock, CJ .
NATURE, 1997, 389 (6650) :498-501
[3]   Incubation period of Creutzfeldt-Jakob disease in human growth hormone recipients in France [J].
d'Aignaux, JH ;
Costagliola, D ;
Maccario, J ;
de Villemeur, TB ;
Brandel, JP ;
Deslys, JP ;
Hauw, JJ ;
Chaussain, JL ;
Agid, Y ;
Dormont, D ;
Alpérovitch, A .
NEUROLOGY, 1999, 53 (06) :1197-1201
[4]   Increased susceptibility to Kuru of carriers of the PRNP 129 methionine/methionine genotype [J].
Lee, HS ;
Brown, P ;
Cervenáková, L ;
Garruto, RM ;
Alpers, MP ;
Gajdusek, DC ;
Goldfarb, LG .
JOURNAL OF INFECTIOUS DISEASES, 2001, 183 (02) :192-196
[5]  
Will RG, 2000, ANN NEUROL, V47, P575